Avatrombopag Impurity 12 CAS 762237-66-1
| CAS No. | 762237-66-1 |
| Molecular Formula | C23H25Cl2N5O2S2 |
| Molecular Weight | 538.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avatrombopag Impurity 12.
Avatrombopag Impurity 12 (CAS 762237-66-1) is a certified pharmaceutical impurity reference standard with the molecular formula C23H25Cl2N5O2S2 and a molecular weight of 538.51 g/mol.
The molecular framework of Avatrombopag Impurity 12 (C23H25Cl2N5O2S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Avatrombopag Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H25Cl2N5O2S2 |
| Molecular Weight | 538.51 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 141 (CAS 570403-05-3)
- Avatrombopag Impurity 82 (CAS CATO-C4X-223482)
- Avatrombopag Impurity 62 (CAS 570403-04-2)
- Avatrombopag Impurity 101 (CAS CATO-C4X-2234101)
- Avatrombopag Impurity 83 (CAS CATO-C4X-223483)
- Avatrombopag Impurity 1 (CAS 2626934-45-8)
- Avatrombopag impurity 133 (CAS CATO-C4X-2234133)
- Avatrombopag Impurity 14 (CAS CATO-C4X-223414)
Recommended Standards
- Azilsartan impurity 147 (CAS CATO-C4X-1096147)
- Methyl 1-benzyl-3-(4-methoxyphenyl)-4,6-dioxo-5-(3-(trifluoromethyl)phenyl)octahydropyrrolo[3,4-c]pyrrole-1-carboxylate (CAS 318239-71-3)
- Delamanid-D4 (CAS CATO-C4X-2514)
- 6-Feruloylcatalpol (CAS 770721-33-0)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
- Rosuvastatin Impurity 60 (CAS 2162136-65-2)
- Cabazitaxel Impurity 6 (CAS CATO-C4X-11156)
- 2-Amino-N-((1S)-2-(dimethylamino)cyclohexyl)-N-ethyl-3-methylbutanamide (CAS 1354026-46-2)
- 3-Amino-3-(3-methoxyphenyl)propionic Acid (CAS 68208-19-5)
- 4-(2,4-Difluorophenoxy)phenol (CAS 123599-90-6)
- 2,4-Dichloro-N-(2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-5-(trifluoromethyl)phenyl)benzamide (CAS 478262-10-1)
- 5-Bromo-2-iodo-3-nitrobenzoic acid (CAS 855749-52-9)
- (E)-4-(4-Isopropylphenyl)-4-oxobut-2-enoic acid (CAS 29587-82-4)
- Des-Ile17-Tirzepatide (CAS CATO-CPTD788956)
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