Avatrombopag Impurity 1 CAS 2626934-45-8
| CAS No. | 2626934-45-8 |
| Molecular Formula | C25H30Cl2N6OS2 |
| Molecular Weight | 565.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Avatrombopag Impurity 1 (C25H30Cl2N6OS2) contains a steroid core, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 565.58 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Avatrombopag Impurity 1 (CAS 2626934-45-8, C25H30Cl2N6OS2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Avatrombopag Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H30Cl2N6OS2 |
| Molecular Weight | 565.58 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag impurity 133 (CAS CATO-C4X-2234133)
- Avatrombopag Impurity 7 (CAS CATO-C4X-22347)
- Avatrombopag Impurity 101 (CAS CATO-C4X-2234101)
- Avatrombopag Impurity 62 (CAS 570403-04-2)
- Avatrombopag Impurity 82 (CAS CATO-C4X-223482)
- Avatrombopag Impurity 12 (CAS 762237-66-1)
- Avatrombopag Impurity 141 (CAS 570403-05-3)
- Avatrombopag Impurity 105 (CAS CATO-C4X-2234105)
Recommended Standards
- N-Benzoyl-N-(8-(benzyloxy)-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 142979-39-3)
- Z-Gly-Ala-Gln-AMC (CAS 201928-35-0)
- Lasmiditan Impurity 70 (CAS CATO-C4X-247870)
- Z-Ala-Ala-Asn-AMC (CAS 149697-16-5)
- Atropine Impurity 19 (CAS 14510-37-3)
- Mirabegron impurity 95 (CAS CATO-C4X-103295)
- Lifitegrast Impurity 83 (CAS CATO-C4X-240983)
- 0816AF 856336-39-5 C10H11NO3 [(2,4-Dimethylphenyl)amino](oxo)acetic acid (CAS 856336-39-5)
- 4-[2-(2,5-Dichlorophenoxy)ethyl]piperidinehydrochloride (CAS 1220031-65-1)
- 2-[2-(2,4-Dichlorophenoxy)ethyl]piperidinehydrochloride (CAS 1219972-68-5)
- 2-Ethynyl-5-fluoro-3-methylpyridine (CAS 1372103-93-9)
- 3984-22-3 2-Vinyl-1,3-dioxolane 1,3-Dioxolane, 2-ethenyl- EINECS 223-626-8 (CAS 3984-22-3)
- 3,3'-Bipyridazine (CAS 10198-96-6)
- Semaglutide impurity 30 (CAS CATO-C4X-222630)
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