Verapamil Impurity 18 CAS 66618-12-0
| CAS No. | 66618-12-0 |
| Molecular Formula | C14H22BrNO2 |
| Molecular Weight | 316.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Verapamil Impurity 18 (CAS 66618-12-0) is a certified pharmaceutical impurity reference standard with the molecular formula C14H22BrNO2 and a molecular weight of 316.23 g/mol.
Verapamil Impurity 18 (C14H22BrNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H22BrNO2 |
| Molecular Weight | 316.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Verapamil Standards
- Verapamil EP Impurity F (CAS 34245-14-2)
- Verapamil Impurity 33 (CAS 27487-66-7)
- Verapamil Impurity 20 (CAS 27339-25-9)
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil EP Impurity D (CAS 36770-74-8)
- Verapamil Impurity 17 (CAS CATO-C4X-177817)
- Verapamil Impurity 19 (CAS CATO-C4X-177819)
- Verapamil Impurity 51 (CAS CATO-C4X-177851)
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