Gliquidone Impurity 1 CAS 76746-95-7
| CAS No. | 76746-95-7 |
| Molecular Formula | C11H11NO3 |
| Molecular Weight | 205.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Gliquidone Impurity 1.
As a process- or degradation-related impurity, Gliquidone Impurity 1 (CAS 76746-95-7, C11H11NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Gliquidone Impurity 1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 205.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11NO3 |
| Molecular Weight | 205.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 1 |
Related Gliquidone Standards
- Gliquidone Impurity 7 (CAS 1136-01-2)
- Gliquidone Impurity 4 (CAS 33214-38-9)
- Gliquidone Impurity 6 (CAS 51632-31-6)
- Gliquidone Impurity 1 (CAS 52962-25-1)
- Gliquidone Impurity 8 (CAS 1133-54-6)
- Gliquidone Impurity 3 (CAS 55974-25-9)
- Gliquidone Impurity 9 (CAS 58202-95-2)
- Gliquidone Impurity 4 (CAS 191988-38-2)
Recommended Standards
- Ozanimod Impurity 29 (CAS CATO-C4X-29029)
- Fruquintinib Impurity 13 (CAS CATO-C4X-303713)
- Ozanimod Impurity 27 (CAS CATO-C4X-29027)
- Selumetinib Impurity 18 (CAS CATO-C4X-305318)
- Betamethasone Valerate EP Impurity B (CAS 1879-77-2)
- Olopatadine Impurity 12 (CAS 66801-40-9)
- Clopidogrel EP impurity D Sulfate (CAS 1421283-60-4 (free base))
- 2,3,5,6-Tetrafluoro-4-hydrazinylpyridine (CAS 1735-44-0)
- (S)-1-(6-Ethoxy-2-(methylthio)pyrimidin-4-yl)pyrrolidin-3-ol (CAS 1354018-60-2)
- 3-Methyl-5-oxo-5-(4-phenoxyphenyl)pentanoic acid (CAS 64157-56-8)
- (S)-2-Amino-8-(tert-butoxy)-8-oxooctanoic acid (CAS 276869-42-2)
- 4-(Cyclopropylmethoxy)-3-propylbenzaldehyde (CAS 883528-79-8)
- N-(9-Ethyl-9H-carbazol-3-yl)-2-(4-methyl-2,5-dioxo-4-(p-tolyl)imidazolidin-1-yl)acetamide (CAS 956357-71-4)
- Prolactin-Releasing Peptide (12-31), rat (CAS 222988-10-5)
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