Betamethasone Valerate EP Impurity B CAS 1879-77-2
| CAS No. | 1879-77-2 |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Betamethasone Valerate EP Impurity B is closely related to a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Betamethasone Valerate EP Impurity B (CAS 1879-77-2, C22H29FO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H29FO4, Betamethasone Valerate EP Impurity B contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 376.46 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Betamethasone Valerate EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Betamethasone Standards
- Betamethasone Impurity 125 (CAS CATO-C4X-1437125)
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- Betamethasone Impurity 9 (CAS 2597-76-4)
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Recommended Standards
- 6-beta-Methyl Fluorometholone (CAS 3918-13-6)
- Dexamethasone EP Impurity F (CAS 382-67-2)
- Fluorometholone D Homo Derivative (CAS CATO-C4X-19339)
- Dexamethasone Isonicotinate EP Impurity C (CAS 426-15-3)
- Aprepitant Impurity 68 (CAS CATO-C4X-114168)
- Meropenem Impurity 36 (CAS CATO-C4X-130936)
- Argatroban Impurity 118 (CAS CATO-C4X-1007118)
- N-(5-Methyl-1H-pyrazol-3-yl)butyramide (CAS 714230-79-2)
- (S)-(3-(Hydroxymethyl)tetrahydrofuran-3-yl)methanesulfonate (CAS 941692-36-0)
- 1-Pyridin-2-yl-[1,4]diazepane (CAS 287114-32-3)
- 3-(4-Bromobutyl)thiazol-2(3h)-one (CAS 1343773-65-8)
- 2-(1H-pyrrol-1-yl)ethanol (CAS 6719-02-4)
- 5-Methyl-N-(4-methylphenyl)-12-oxo-5H,5aH,6H,7H,8H,9H,10H,12H-azepino[2,1-b]quinazoline-3-carboxamide (CAS 1775357-60-2)
- Peptide 441 (CAS CATO-CPTD788441)
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