Selumetinib Impurity 18 CAS CATO-C4X-305318
| CAS No. | CATO-C4X-305318 |
| Molecular Formula | C10H11N3O2 |
| Molecular Weight | 205.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Selumetinib Impurity 18 (CAS CATO-C4X-305318) is a certified pharmaceutical impurity reference standard with the molecular formula C10H11N3O2 and a molecular weight of 205.21 g/mol.
Selumetinib Impurity 18 (C10H11N3O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11N3O2 |
| Molecular Weight | 205.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Selumetinib Standards
- Selumetinib Impurity 5 (CAS CATO-C4X-30535)
- Selumetinib Impurity 14 (CAS CATO-C4X-305314)
- Selumetinib Impurity 13 (CAS CATO-C4X-305313)
- Selumetinib Impurity 15 (CAS CATO-C4X-305315)
- Selumetinib Impurity N1 (CAS 917980-11-1)
- Selumetinib Impurity 22 (CAS CATO-C4X-305322)
- Selumetinib Impurity 9 (CAS CATO-C4X-30539)
- Selumetinib Impurity 16 (CAS CATO-C4X-305316)
Recommended Standards
- Fruquintinib Impurity 13 (CAS CATO-C4X-303713)
- Ensifentrine impurity 33 (CAS CATO-C4X-335333)
- Gliquidone Impurity 1 (CAS 76746-95-7)
- Tivozanib Impurity 27 (CAS CATO-C4X-340027)
- Arotinolol Impurity 58 (CAS CATO-C4X-185458)
- Esmolol Impurity 18 (CAS CATO-C4X-189118)
- Lodoxamide lmpurity 13 (CAS 53882-13-6)
- 2-Aminooctane (CAS 693-16-3)
- Isopropyl 3-(methylamino)pyrrolidine-1-carboxylate (CAS 1546068-28-3)
- 1-(((5-Methylthiazol-2-yl)methyl)amino)propan-2-ol (CAS 921146-02-3)
- 3-Nitrotoluene (CAS 99-08-1)
- 1-(5-Chloro-2-methylphenyl)-4,4-dimethyl-1,4-dihydropyrimidine-2-thiol (CAS 1142212-27-8)
- 1-Methyl-4-(thiophen-2-yl)pyrrolidin-3-amine (CAS 1483911-93-8)
- Tirzepatide Impurity 52 (CAS CATO-C4X-324052)
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