Acemetacin EP Impurity D CAS 76812-64-1
| CAS No. | 76812-64-1 |
| Molecular Formula | C25H26ClNO6 |
| Molecular Weight | 471.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 471.93 g/mol gives Acemetacin EP Impurity D distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Acemetacin EP Impurity D (CAS 76812-64-1) is a certified pharmaceutical impurity reference standard with the molecular formula C25H26ClNO6 and a molecular weight of 471.93 g/mol.
Based on its molecular formula C25H26ClNO6, Acemetacin EP Impurity D contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 471.93 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H26ClNO6 |
| Molecular Weight | 471.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Acemetacin Standards
- Acemetacin EP Impurity E (CAS 75302-98-6)
- Acemetacin EP Impurity F (CAS 76812-49-2)
- Acemetacin EP Impurity C (CAS CATO-C4X-33821)
- Acemetacin-D4 (CAS 1196151-16-2)
- Acemetacin (CAS 53164-05-9)
- Acemetacin acyl-β-D-glucuronide (CAS 1260603-31-3)
- Acemetacin Impurity 1 (CAS 77914-62-6)
- Acemetacin EP Impurity B Potassium Salt (CAS 28751-45-3)
Recommended Standards
- 2-(((4-(3,4,5-Tribromo-1H-pyrazol-1-yl)phenyl)amino)methylene)malononitrile (CAS 219793-56-3)
- 1-(5-Chloro-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-3-(2-methyl-7-morpholinothiazolo[5,4-b]pyridin-6-yl)urea (CAS 2178989-63-2)
- 4-(Benzo[d]thiazol-2-ylthio)-3-nitrobenzyl (3-chlorophenyl)carbamate (CAS 338393-84-3)
- Afatinib Impurity 10 (CAS CATO-C4X-100610)
- Levetiracetam Impurity 36 (CAS 18017-35-1)
- Dextromethorphan Impurity 18 HCl (CAS CATO-C4X-115718)
- Domperidone Impurity 13 (CAS 87120-77-2)
- Mal-amido-PEG7-acid (CAS 2112731-42-5)
- Tert-butyl 3,4,4a,5,6,7-hexahydro-1,5-naphthyridine-1(2H)-carboxylate (CAS 2716849-50-0)
- 2-(Benzylamino)-4-methylpyrimidine-5-carboxylic acid (CAS 857410-55-0)
- N1,N1,N1,N3,N3,N3-Hexamethylpropane-1,3-diaminium chloride (CAS 56971-22-3)
- tert-Butyl (3-bromo-4-oxocyclohexyl)carbamate (CAS 1073632-93-5)
- 4-{2-[2-(2,4-Dibromo-6-methylphenoxy)acetyl]hydrazino}-4-oxobutanoic acid (CAS 458551-03-6)
- Neuropeptide S (human) (CAS 412938-67-1)
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