Gefitinib impurity 72 CAS 770-22-9
| CAS No. | 770-22-9 |
| Molecular Formula | C7H5ClFNO |
| Molecular Weight | 173.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 173.57 g/mol gives Gefitinib impurity 72 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Gefitinib impurity 72 (CAS 770-22-9), a pharmacopoeial impurity reference standard (molecular formula C7H5ClFNO, MW 173.57 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Gefitinib impurity 72 (C7H5ClFNO) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 173.57 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Gefitinib impurity 72 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5ClFNO |
| Molecular Weight | 173.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Gefitinib Standards
- Gefitinib Impurity 45 (CAS 350-30-1)
- Gefitinib Impurity 46 (CAS 2106-49-2)
- Gefitinib Impurity 12 (CAS 7357-67-7)
- Gefitinib Impurity 34 (CAS 194423-17-1)
- Gefitinib Impurity 85 (CAS CATO-C4X-111785)
- Gefitinib Impurity 4 (CAS 179688-52-9)
- Gefitinib Impurity 8 (CAS 379228-50-9)
- Gefitinib Impurity 28 (CAS 1379208-77-1)
Recommended Standards
- alpha-Chloro-4-fluorobenzaldoxime (CAS 393165-20-3)
- 2-Nitroethane-1-sulfonyl chloride (CAS 97925-84-3)
- alpha-Chloro-3-fluorobenzaldoxime (CAS 58606-42-1)
- Methyl n-(chlorosulfonyl)carbamate (CAS 36914-92-8)
- Lefamulinum Impurity 31 (CAS CATO-C4X-304731)
- Nicorandil Impurity 18 (CAS CATO-C4X-190718)
- Metoclopramide Impurity 107 (CAS CATO-C4X-1415107)
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- Methyl 4-(dimethoxymethyl)-6,8-difluoroquinoline-2-carboxylate (CAS 2757622-18-5)
- 3,5-Diaminophenol dihydrochloride (CAS 99761-37-2)
- 1,2-Diphenyl-1-(4-hydroxyphenyl)ethanol (CAS 355803-76-8)
- Sodium diethylglycinate (CAS 5426-55-1)
- tert-butyl (2S)-1-(chlorosulfonyl)pyrrolidine-2-carboxylate (CAS 1955473-63-8)
- Peptide YY (3-36) (human) (CAS 123583-37-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com