Gefitinib Impurity 12 CAS 7357-67-7
| CAS No. | 7357-67-7 |
| Molecular Formula | C7H14ClNO |
| Molecular Weight | 163.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Gefitinib Impurity 12 (C7H14ClNO) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Gefitinib Impurity 12 (CAS 7357-67-7, C7H14ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Gefitinib Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H14ClNO |
| Molecular Weight | 163.65 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Gefitinib Standards
- Gefitinib impurity 72 (CAS 770-22-9)
- Gefitinib Impurity 45 (CAS 350-30-1)
- Gefitinib Impurity 46 (CAS 2106-49-2)
- Gefitinib Impurity 22 (CAS 52805-46-6)
- Gefitinib Impurity 11 (CAS 367-21-5)
- Gefitinib Impurity 44 (CAS 367-22-6)
- Gefitinib Impurity 34 (CAS 194423-17-1)
- Gefitinib Impurity 85 (CAS CATO-C4X-111785)
Recommended Standards
- 3-Chloro-o-anisidine 3-chloro-2-methoxyaniline 51114-68-2 (CAS 51114-68-2)
- 2-chloro-4H-thieno[3,2-b]pyrrole (CAS 1430411-08-7)
- n-Tert-butyl-2-chloropropanamide (CAS 94318-74-8)
- N-(2-chloroprop-2-en-1-yl)thietan-3-amine (CAS 1849288-82-9)
- Progesterone Impurity 72 (CAS 93519-10-9)
- Vonoprazan Impurity 303 (CAS CATO-C4X-1020303)
- Imatinib Impurity 41 (CAS CATO-C4X-106841)
- 2-(2-(1H-imidazol-1-yl)pyrimidin-5-yl)ethan-1-amine (CAS 944899-35-8)
- N-Ethyl-2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 1220696-22-9)
- Florfenicol Impurity 70 (CAS 126428-97-5)
- 2-((Benzyloxy)methyl)cyclopent-3-enol (CAS 959973-63-8)
- 4-tert-Butylaniline p-tertbutyl aniline 4-(tert-butyl)aniline p-tert-butylaniline benzenamine, 4-(1,1-dimethylethyl)- p-t-butylaniline 769-92-6 (CAS 769-92-6)
- 3-Chloro-5-fluoro-3-(3-methylphenyl)propiophenone (CAS 898791-17-8)
- Semaglutide Impurity 142 (CAS CATO-C4X-2226142)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com