Ataluren Impurity 5 CAS 775304-28-4
| CAS No. | 775304-28-4 |
| Molecular Formula | C15H9ClN2O3 |
| Molecular Weight | 300.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 300.70 g/mol gives Ataluren Impurity 5 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ataluren Impurity 5 (CAS 775304-28-4) is a certified pharmaceutical impurity reference standard with the molecular formula C15H9ClN2O3 and a molecular weight of 300.70 g/mol.
The molecular framework of Ataluren Impurity 5 (C15H9ClN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ataluren Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H9ClN2O3 |
| Molecular Weight | 300.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ataluren Standards
- Ataluren Impurity 11 (CAS CATO-C4X-300611)
- Ataluren Impurity 14 (CAS CATO-C4X-300614)
- Ataluren Impurity 4 (CAS CATO-C4X-30064)
- Ataluren Impurity 16 (CAS CATO-C4X-300616)
- Ataluren Impurity 12 (CAS CATO-C4X-300612)
- Ataluren Impurity 1 (CAS CATO-C4X-30068)
- Ataluren (CAS 775304-57-9)
- Ataluren Impurity N (CAS 775304-56-8)
Recommended Standards
- Inosine impurity 10 (CAS 146196-07-8)
- 2-[1-(4-Chloro-3-fluorobenzyl)-3-oxo-2-piperazinyl]acetic acid (CAS 1033600-01-9)
- Baricitinib Impurity 109 (CAS CATO-C4X-2260109)
- 2-(1-(2-Chloro-6-fluorobenzyl)-3-oxopiperazin-2-yl)acetic acid (CAS 1033600-27-9)
- Methylnaltrexone Bromide Impurity 15 (CAS CATO-C4X-152115)
- Tolterodine Impurity 9 (CAS 854306-72-2)
- Cefodizime Impurity 21 (CAS 60846-14-2)
- 7-(Pyrrolidin-1-yl)heptan-1-amine (CAS 1020937-83-0)
- 4-Pyrrolidinomethyl-2-trifluoromethylbenzophenone (CAS 898776-65-3)
- (R)-tert-Butyl (1-chloropropan-2-yl)carbamate (CAS 193761-47-6)
- (4-Bromo-thiophen-3-ylmethyl)-methyl-amine (CAS 921938-63-8)
- 4-(2-Fluoro-4-(trifluoromethyl)phenyl)pyridine (CAS 1214380-57-0)
- 3-(4-Bromophenoxy)pyridazine (CAS 40890-13-9)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
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