Nitrofurantoin Impurity 2 CAS 777-34-4
| CAS No. | 777-34-4 |
| Molecular Formula | C8H7N3O3 |
| Molecular Weight | 193.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nitrofurantoin Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Nitrofurantoin Impurity 2 (CAS 777-34-4) is a certified pharmaceutical impurity reference standard with the molecular formula C8H7N3O3 and a molecular weight of 193.16 g/mol.
The molecular framework of Nitrofurantoin Impurity 2 (C8H7N3O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H7N3O3 |
| Molecular Weight | 193.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 3 |
Related Nitrofurantoin Standards
- Nitrofurantoin Impurity N1 (CAS 91447-38-0)
- Nitrofurantoin (CAS 67-20-9)
- Nitrofurantoin RC 1 (CAS 25004-91-5)
- Nitrofurantoin-13C3 (CAS 1217226-46-4)
- Nitrofurantoin impurity 1 (CAS CATO-C4X-30861)
- Nitrofurantoin Impurity 3 (CAS CATO-C4X-30863)
- Nitrofurantoin Monohydrate (CAS 17140-81-7)
- Nitrofurantoin Impurity 3 (CAS 1749-92-4)
Recommended Standards
- Epinephrine /Adrenaline Impurity 133 (CAS CATO-C4X-1849133)
- Toxoflavin (CAS 84-82-2)
- Levodopa Impurity 8 (CAS 4790-08-3)
- trans-2-Nitrocinnamic acid (CAS 612-41-9)
- Lornoxicam Impurity 23 (CAS CATO-C4X-201623)
- Emtricitabine Impurity 24 (CAS CATO-C4X-123224)
- Azostatin Impurity 43 (CAS CATO-C4X-139643)
- 3-(Furan-2-ylmethyl)quinazoline-2,4(1H,3H)-dione (CAS 436855-78-6)
- 5-(4-Chlorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine (CAS 1369374-16-2)
- N-Benzyl-3-(5-(3-nitrophenyl)furan-2-yl)acrylamide (CAS 853351-47-0)
- 2,5-Dichloro-8-methoxyquinoline (CAS 74668-75-0)
- 5-(4-Chlorophenyl)-3-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrimidine (CAS 866144-81-2)
- 2-(6-(2-Aminoethyl)pyridin-2-yl)propan-2-ol (CAS 2798825-95-1)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com