Bortezomib Impurity 44 CAS 78-77-3

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.78-77-3
Molecular FormulaC4H9Br
Molecular Weight137.02 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Bortezomib Impurity 44 CAS 78-77-3 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 137.02 g/mol gives Bortezomib Impurity 44 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Bortezomib Impurity 44 (CAS 78-77-3) is a certified pharmaceutical impurity reference standard with the molecular formula C4H9Br and a molecular weight of 137.02 g/mol.

Structurally, Bortezomib Impurity 44 (C4H9Br) contains bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 0.0, corresponding to approximately 0 ring(s) or double-bond equivalent(s). With a molecular weight of 137.02 g/mol, it falls into the low-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Bortezomib Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC4H9Br
Molecular Weight137.02 g/mol
Purity>95%
StorageStore at 2-8°C, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO
StabilityStable under recommended storage conditions
Degree of Unsaturation (DBE)0.0
CAS Registry Year (est.)1957
Halogen ContentBr-containing

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