S-Chlorpheniramine N-0xide CAS 142494-46-0
| CAS No. | 142494-46-0 |
| Molecular Formula | C16H19ClN2O |
| Molecular Weight | 290.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 290.79 g/mol gives S-Chlorpheniramine N-0xide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies S-Chlorpheniramine N-0xide (CAS 142494-46-0), a certified reference material (molecular formula C16H19ClN2O, MW 290.79 g/mol) for analytical method development and quality control.
The molecular framework of S-Chlorpheniramine N-0xide (C16H19ClN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H19ClN2O |
| Molecular Weight | 290.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related S Standards
- R-Chlorpheniramine N-Oxide (CAS 142494-45-9)
- Chlorpheniramine Impurity 15 (CAS 120244-82-8)
- Chlorpheniramine Impurity 14 (CAS CATO-C4X-118814)
- Chlorpheniramine-d6 (CAS 1185054-60-7)
- Chlorpheniramine Nitrile-d6 (CAS 1329488-38-1)
- Chlorpheniramine Impurity 19 (CAS CATO-C4X-118819)
- Chlorpheniramine Impurity 36 (CAS CATO-C4X-118836)
- Chlorpheniramine Impurity 38 (CAS CATO-C4X-118838)
Recommended Standards
- Chlorphenamine impurity 54 (CAS CATO-C4X-118854)
- Chlorphenamine Impurity 7 (CAS 78180-89-9)
- 3-(4-tert-Butylphenoxy)propane-1-sulfonyl chloride (CAS 1018288-96-4)
- Mirabegron impurity 122 (CAS 391901-43-2)
- Haemanthamine (CAS 466-75-1)
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