Flumazenil Impurity 8 CAS 78755-82-5
| CAS No. | 78755-82-5 |
| Molecular Formula | C14H12FN3O3 |
| Molecular Weight | 289.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Flumazenil Impurity 8 (CAS 78755-82-5) is a certified pharmaceutical impurity reference standard with the molecular formula C14H12FN3O3 and a molecular weight of 289.26 g/mol.
The molecular framework of Flumazenil Impurity 8 (C14H12FN3O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12FN3O3 |
| Molecular Weight | 289.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Flumazenil Standards
- Flumazenil (N-[11C]Methyl) EP Impurity A (CAS 79089-72-8)
- Flumazenil Impurity 14 (CAS 1291916-17-0)
- Flumazenil EP Impurity E (CAS 78756-03-3)
- Flumazenil Impurity 21 (CAS CATO-C4X-143221)
- Flumazenil Impurity 20 (CAS CATO-C4X-143220)
- Flumazenil EP Impurity B (CAS 131666-45-0)
- Flumazenil Impurity 12 (CAS CATO-C4X-143212)
- Flumazenil EP Impurity A (CAS 84378-44-9)
Recommended Standards
- Ethyl 2-(5-(trifluoromethyl)benzo[d]thiazol-2-yl)acetate (CAS 1126637-92-0)
- Amisulpride Impurity 43 (CAS 79893-22-4)
- Ethyl 3-amino-5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate (CAS 1217018-83-1)
- N-(4-(Trifluoromethyl)phenyl)quinazolin-4-amine (CAS 849589-40-8)
- Pemetrexed Impurity 21 (CAS 1001-19-0)
- Desmopressin Impurity 37 (CAS CATO-C4X-221537)
- Ezetimibe Impurity 94 (CAS CATO-C4X-109894)
- N-(3-Acetylamino-4-methoxy-phenyl)-2-chloro-acetamide (CAS 936820-39-2)
- (R)-2-methylpiperidine-2-carboxylic acid (CAS 105141-61-5)
- 2-Chloro-N-(3-chlorophenyl)-5-(N,N-diethylsulfamoyl)benzamide (CAS 1153537-12-2)
- Methyl 6-(trifluoromethoxy)-1H-benzo[d]imidazole-2-carboxylate (CAS 1805695-63-9)
- 2-methanesulfonyl-1-methyl-5-nitro-1H-imidazole (CAS 1615-53-8)
- 4-(Azepan-1-ylmethyl)-5-methylthiophene-2-carbaldehyde (CAS 889973-25-5)
- Semaglutide impurity 66 (CAS CATO-C4X-222666)
Why CATO?
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