Lasmiditan Impurity 1 CAS 79538-29-7
| CAS No. | 79538-29-7 |
| Molecular Formula | C7H2ClF3O |
| Molecular Weight | 194.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lasmiditan Impurity 1 is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lasmiditan Impurity 1 (CAS 79538-29-7, C7H2ClF3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lasmiditan Impurity 1 (C7H2ClF3O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 194.54 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lasmiditan Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H2ClF3O |
| Molecular Weight | 194.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F/Cl-containing |
Related Lasmiditan Standards
- Lasmiditan Impurity 32 (CAS 3355-39-3)
- Lasmiditan Impurity 33 (CAS CATO-C4X-247833)
- Lasmiditan Impurity 4 (CAS 103640-16-0)
- Lasmiditan Impurity 8 (CAS 517875-04-6)
- Lasmiditan Impurity 19 (CAS 1903-67-9)
- Lasmiditan Impurity 6 (CAS 28314-80-9)
- Lasmiditan Impurity 2 (CAS 613678-03-8)
- Lasmiditan Impurity 40 (CAS CATO-C4X-247840)
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