Sertraline Impurity 64 CAS 79560-20-6
| CAS No. | 79560-20-6 |
| Molecular Formula | C17H15Cl2N |
| Molecular Weight | 304.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sertraline Impurity 64 (C17H15Cl2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Sertraline Impurity 64 (CAS 79560-20-6) is a certified pharmaceutical impurity reference standard with the molecular formula C17H15Cl2N and a molecular weight of 304.21 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H15Cl2N |
| Molecular Weight | 304.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sertraline Standards
- Sertraline oxime Impurity (CAS 152642-35-8)
- Sertraline Impurity 51 (CAS CATO-C4X-134451)
- Sertraline Impurity C49 (CAS 140631-53-4)
- Sertraline EP Impurity G (CAS 79617-98-4)
- Sertraline Impurity 53 (CAS 2184053-08-3)
- Sertraline (CAS 79617-96-2)
- Sertraline EP Impurity A (CAS 79836-45-6)
- Sertraline Impurity 72 (CAS CATO-C4X-134472)
Recommended Standards
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- tert-Butyl 1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate (CAS 2865130-22-7)
- 2-Amino-N-benzyl-N-ethylpentanamide (CAS 1218678-74-0)
- N-Acetyl-L-Selenomethionin (CAS 210910-25-1)
- rel-(1R,2R,6R)-7,7-Difluorobicyclo[4.1.0]Heptan-2-ol (CAS 131262-29-8)
- 2-carbamoylfuran-3-carboxylic acid (CAS 1849268-85-4)
- Serpent Peptide (CAS 823202-99-9)
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