Fluocinolone Acetonide EP Impurity L CAS 1893-65-8
| CAS No. | 1893-65-8 |
| Molecular Formula | C24H30ClFO6 |
| Molecular Weight | 468.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Fluocinolone Acetonide EP Impurity L (CAS 1893-65-8) is a certified pharmaceutical impurity reference standard with the molecular formula C24H30ClFO6 and a molecular weight of 468.94 g/mol.
Structurally, Fluocinolone Acetonide EP Impurity L (C24H30ClFO6) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 468.94 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H30ClFO6 |
| Molecular Weight | 468.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Fluocinolone Standards
- Fluocinolone Acetonide EP Impurity A (CAS 106931-78-6)
- Fluocinolone Acetonide Impurity 44 (CAS 54605-01-5)
- Fluocinolone Acetonide Impurity N1 (CAS 6598-95-4)
- Fluocinolone Acetonide Impurity 45 (CAS 39987-51-4)
- Fluocinolone Acetonide impurity 19 (CAS CATO-C4X-238119)
- Fluocinolone Acetonide impurity 20 (CAS CATO-C4X-238120)
- Fluocinolone Acetonide Impurity N3 (CAS 72498-89-6)
- Fluocinolone Acetonide Impurity 33 (CAS CATO-C4X-238133)
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