Telmisartan EP Impurity E CAS 884330-12-5
| CAS No. | 884330-12-5 |
| Molecular Formula | C26H24N2O4 |
| Molecular Weight | 428.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Telmisartan EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 428.48 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Telmisartan EP Impurity E (CAS 884330-12-5, C26H24N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H24N2O4 |
| Molecular Weight | 428.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
Related Telmisartan Standards
- Telmisartan Impurity 45 (CAS 1098100-86-7)
- Telmisartan Impurity 80 (CAS CATO-C4X-135980)
- Telmisartan Impurity 47 (CAS 884330-11-4)
- Telmisartan Impurity 93 (CAS CATO-C4X-135993)
- Telmisartan Impurity 70 (CAS CATO-C4X-135970)
- Telmisartan Impurity 64 (CAS CATO-C4X-135964)
- Telmisartan Impurity 17 (CAS 1352492-08-0)
- Telmisartan Impurity 41 (CAS 1004548-55-3)
Recommended Standards
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- 1-[3-(prop-2-yn-1-yloxy)phenyl]ethan-1-amine (CAS 1182989-98-5)
- BW 1843U89 (CAS 139987-54-5)
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