Roxadustat Impurity N1 CAS 808116-52-1
| CAS No. | 808116-52-1 |
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Roxadustat Impurity N1 (CAS 808116-52-1, C18H15NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Roxadustat Impurity N1 (C18H15NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 309.32 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15NO4 |
| Molecular Weight | 309.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 1 |
Related Roxadustat Standards
- Roxadustat Impurity 39 (CAS CATO-C4X-221339)
- Roxadustat Impurity 73 (CAS CATO-C4X-221373)
- Roxadustat Impurity N3 (CAS 1421312-34-6)
- Roxadustat Impurity 48 (CAS CATO-C4X-221348)
- Roxadustat Impurity 165 (CAS CATO-C4X-2213165)
- Roxadustat Impurity 89 (CAS CATO-C4X-221389)
- Roxadustat Impurity 92 (CAS CATO-C4X-221392)
- Roxadustat Impurity N6 (CAS 1421312-32-4)
Recommended Standards
- Ethyl 1-(4-methyl-6-phenylpyrimidin-2-yl)-1H-1,2,3-triazole-4-carboxylate (CAS 866040-37-1)
- H-Arg(NO2)-OBzl p-tosylate salt (CAS 7672-27-7)
- Ethyl 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-((diethylamino)methyl)-1H-1,2,3-triazole-4-carboxylate (CAS 311321-80-9)
- H-Gly-Phe-Ser-Oh (CAS 23828-14-0)
- Rivaroxaban Impurity 61 (CAS 89166-94-9)
- Lemborexant Impurity 105 (CAS CATO-C4X-3042105)
- Halcinonide Impurity 4 (CAS CATO-C4X-27954)
- 3-Amino-3-[4-(methylsulfanyl)phenyl]propanoic acid (CAS 412925-13-4)
- 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,3-diol (CAS 28122-52-3)
- Methyl N-(2-methoxy-5-methylphenyl)-N-(methylsulfonyl)glycinate (CAS 425616-95-1)
- 5,5-Difluoropiperidin-3-one (CAS 1304192-58-2)
- 4-(Aminomethyl)-2-bromo-5-(difluoromethyl)nicotinic acid (CAS 1805352-50-4)
- 5-Amino-1-(3-bromophenyl)-1H-pyrazole-4-carboxamide (CAS 1394755-36-2)
- Peptide 435 (CAS CATO-CPTD788435)
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