Roxadustat Impurity 165 CAS CATO-C4X-2213165
| CAS No. | CATO-C4X-2213165 |
| Molecular Formula | C15H12Cl2O3 |
| Molecular Weight | 311.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C15H12Cl2O3, Roxadustat Impurity 165 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 311.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Roxadustat Impurity 165 (CAS CATO-C4X-2213165, C15H12Cl2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Roxadustat Impurity 165 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12Cl2O3 |
| Molecular Weight | 311.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Roxadustat Standards
- Roxadustat Impurity 89 (CAS CATO-C4X-221389)
- Roxadustat Impurity 92 (CAS CATO-C4X-221392)
- Roxadustat Impurity N6 (CAS 1421312-32-4)
- Roxadustat Impurity N1 (CAS 808116-52-1)
- Roxadustat Impurity 39 (CAS CATO-C4X-221339)
- Roxadustat Impurity 73 (CAS CATO-C4X-221373)
- Roxadustat Impurity N3 (CAS 1421312-34-6)
- Roxadustat Impurity 86 (CAS CATO-C4X-221386)
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- Tenofovir alafenamide impurity N1 (CAS 16958-60-4)
- Aminomethylbenzoic Acid Impurity 1 (CAS 14900-61-9)
- Diltiazem Impurity N2 (CAS 42399-50-8)
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- 2-Chloro-4-(4-pyrazolyl)pyrimidine (CAS 1206679-17-5)
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- 3,5,8-Trimethyl-[1,2,4]triazolo[4,3-c]pyrimidine (CAS 342617-17-8)
- 2-(3-Chlorophenyl)-5-methyl-4-(piperazin-1-ylmethyl)oxazole (CAS 1030135-90-0)
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