Buspirone EP Impurity B bromide CAS 81461-73-6
| CAS No. | 81461-73-6 |
| Molecular Formula | C12H19N4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Buspirone EP Impurity B bromide is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Buspirone EP Impurity B bromide (CAS 81461-73-6, C12H19N4Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution, Buspirone EP Impurity B bromide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 299.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19N4 Br |
| Molecular Weight | 299.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Buspirone Standards
- Buspirone impurity 01 (CAS 105496-33-1)
- Buspirone EP Impurity K (CAS 1075-89-4)
- Buspirone EP Impurity A-d8 (Buspirone USP Related Compound A-d8) (CAS 1309283-31-5)
- Buspirone Impurity 9 (CAS 13220-24-1)
- Buspirone Impurity 21 (CAS 137583-05-2)
- Buspirone Impurity 24 (CAS 1800242-04-9)
- Buspirone Impurity 20 (CAS 1821194-01-7)
- Buspirone Impurity 23 (CAS 20261-27-2)
Recommended Standards
- Apomorphine Impurity N1 (CAS 18605-40-8)
- Ilaprazole Impurity 160 (CAS CATO-C4X-1130160)
- Finerenone Impurity 144 (CAS CATO-C4X-2880144)
- 3-tert-butylazetidine hydrochloride (CAS 1909306-58-6)
- 2-Chloro-4-[(4-methylphenyl)sulfanyl]pyrimidine (CAS 213747-65-0)
- Dotinurad Impurity 61 (CAS 428458-98-4)
- 6-Chloro-1H-pyrazolo[3,4-b]pyridine (CAS 63725-51-9)
- 3-(5,7-Dimethyl-2-(methylthio)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)propanoic acid (CAS 852940-50-2)
- 1-[(pyridin-4-yl)methyl]-1h-pyrazol-5-amine (CAS 3524-31-0)
- D-Asp15-Tirzepatide (CAS CATO-CPTD788919)
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