Fluconazole EP Impurity D CAS 81886-51-3
| CAS No. | 81886-51-3 |
| Molecular Formula | C13H13FN6O |
| Molecular Weight | 288.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Fluconazole EP Impurity D (CAS 81886-51-3) is a certified pharmaceutical impurity reference standard with the molecular formula C13H13FN6O and a molecular weight of 288.28 g/mol.
Structurally, Fluconazole EP Impurity D (C13H13FN6O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 288.28 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Fluconazole EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13FN6O |
| Molecular Weight | 288.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Fluconazole Standards
- Fluconazole Impurity 19 (CAS 1348664-75-4)
- Fluconazole Impurity 26 (CAS CATO-C4X-101926)
- Fluconazole Impurity 10 (CAS 163921-61-7)
- Fluconazole Impurity 8 (CAS 163921-62-8)
- Fluconazole EP Impurity A (CAS 89429-59-4)
- Fluconazole EP Impurity A (R-Isomer) (CAS CATO-C4X-101963)
- Fluconazole (CAS 86386-73-4)
- Fluconazole Impurity 37 (CAS CATO-C4X-101937)
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- Mirabegron EP Impurity I (CAS 25952-53-8)
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- N, N- Dimethylalanine HCl (CAS 16708-13-7)
- (1-(Pyrimidin-2-yl)piperidin-4-yl)methanol (CAS 111247-61-1)
- 3-(N-(3-Amino-2,4,6-triiodophenyl)acetamido)-2-methylpropanoic acid (CAS 16034-77-8)
- 3-(Pyridin-3-yl)-2-tosylacrylonitrile (CAS 897296-66-1)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
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