Ramipril Impurity 5 CAS 84324-12-9
| CAS No. | 84324-12-9 |
| Molecular Formula | C15H21NO4 |
| Molecular Weight | 279.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ramipril Impurity 5 (CAS 84324-12-9, C15H21NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ramipril Impurity 5 (C15H21NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ramipril Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H21NO4 |
| Molecular Weight | 279.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 1 |
Related Ramipril Standards
- Ramipril Impurity 4 (CAS 122076-80-6)
- Ramipril Impurity 6 (CAS 85196-26-5)
- Ramipril EP Impurity M (CAS 2743-38-6)
- Ramipril EP Impurity K (CAS 108736-10-3)
- Ramipril EP Impurity E (CAS 87269-97-4)
- Ramipril EP Impurity D (CAS 108731-95-9)
- Ramipril EP Impurity A (CAS 108313-11-7)
- Ramipril EP Impurity L (CAS 1309040-96-7)
Recommended Standards
- Enalapril EP Impurity B (CAS 82717-96-2)
- Tetracaine Impurity 30 (CAS CATO-C4X-192330)
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- Tetracaine Impurity 35 (CAS CATO-C4X-192335)
- Niraparib Impurity 33 (CAS CATO-C4X-232933)
- Sofosbuvir Impurity 2 (CAS 1157884-58-6)
- Sitagliptin Impurity 2 (CAS 769195-20-2)
- (1H-Inden-1-yl)trimethylsilane (CAS 18053-75-3)
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- 5-Chloro-2-ethylpyridine (CAS 1159815-12-9)
- (S)-1-(thiophen-2-yl)prop-2-en-1-amine (CAS 1213006-61-1)
- Des-Gly29,30-Tirzepatide (CAS CATO-CPTD788944)
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