Dexamethasone Impurity 96 CAS 84449-15-0
| CAS No. | 84449-15-0 |
| Molecular Formula | C22H27FO6 |
| Molecular Weight | 406.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dexamethasone Impurity 96 (CAS 84449-15-0, C22H27FO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dexamethasone Impurity 96 (C22H27FO6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H27FO6 |
| Molecular Weight | 406.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone 17-Formyloxy-17-Acid (CAS 473273-04-0)
- Dexamethasone Impurity 61 (CAS CATO-C4X-116561)
- Dexamethasone Acid Ethyl Ester (CAS 2991360-83-7)
- Dexamethasone Impurity N1 (CAS 37926-77-5)
- Dexamethasone Impurity 24 (CAS 55879-47-5)
- Dexamethasone Impurity 97 (CAS CATO-C4X-116597)
- Dexamethasone Impurity 24 (CAS 24510-54-1)
- Dexamethasone EP Impurity B Hydrochloride (CAS 956901-32-9)
Recommended Standards
- Flurbiprofen Impurity 117 (CAS CATO-C4X-1444117)
- Fluvoxamine impurity 49 (CAS CATO-C4X-195149)
- N'-(4-(Diethylamino)benzylidene)-3-(3-nitrophenyl)-1H-pyrazole-5-carbohydrazide (CAS 302918-45-2)
- Betamethasone Impurity N22 (CAS 116522-68-0)
- Topiramate Impurity 41 (CAS CATO-C4X-176841)
- Procaterol Impurity 7 (Enantiomer Mixture) (CAS 72332-33-3)
- Clobetasol Propionate EP Impurity G (CAS 25122-41-2)
- 2-(Isopropylthio)-3-methylnaphthalene-1,4-dione (CAS 66137-78-8)
- Calcium Glycolate (CAS 26257-13-6)
- (R)-4-chloro-6-methyl-2,3-dihydro-1H-inden-1-amine (CAS 1213223-64-3)
- N1,N1-Diethyl-N2-methyl-N2-phenylethane-1,2-diamine (CAS 74474-29-6)
- (4-Chloro-2-pyridinyl)cyclopropyl-methanone (CAS 881204-94-0)
- 5-Chloro-2,8-dimethylquinolin-4-amine (CAS 948292-79-3)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
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