4-Chloro-2-methoxy-6-methyl-5-nitropyrimidine CAS 84538-47-6
| CAS No. | 84538-47-6 |
| Molecular Formula | C6H6ClN3O3 |
| Molecular Weight | 203.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 203.58 g/mol gives 4-Chloro-2-methoxy-6-methyl-5-nitropyrimidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Chloro-2-methoxy-6-methyl-5-nitropyrimidine (CAS 84538-47-6) is a high-purity analytical reference standard with the molecular formula C6H6ClN3O3 and a molecular weight of 203.58 g/mol.
4-Chloro-2-methoxy-6-methyl-5-nitropyrimidine (C6H6ClN3O3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-methoxy-6-methyl-5-nitropyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClN3O3 |
| Molecular Weight | 203.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-Chloro-N-(isoxazol-3-ylcarbamoyl)acetamide (CAS 112810-51-2)
- 4-chloro-2-methoxy-6-nitrophenol (CAS 118724-89-3)
- 3-Chloro-6-(2,2-difluoroethyl)pyrazine-2-carbonitrile (CAS 1257072-46-0)
- 6-Chloro-4-(difluoromethyl)-1H-pyrazolo[3,4-b]pyridine (CAS 1279829-79-6)
- 5-Chloro-4-methoxy-2-nitrophenol (CAS 14164-14-8)
- 2-Chloro-4-ethoxy-5-nitropyrimidine (CAS 1702077-93-7)
- 2-Chloro-4-methoxy-6-methyl-5-nitropyrimidine (CAS 1899-99-6)
- 2-Chloro-5-(difluoromethyl)-5H-pyrrolo[3,2-d]pyrimidine (CAS 1934913-04-8)
Recommended Standards
- 4-Chloro-2-(hydroxymethyl)-6-nitrophenol (CAS 77691-34-0)
- 4-Chloro-5-(difluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 2090261-97-3)
- 4-Chloro-2-(difluoromethyl)pyrazolo[1,5-a]pyrazine (CAS 2138262-83-4)
- 4-chloro-5-methoxy-2-nitrophenol (CAS 88581-05-9)
- N,N-Dimethylbenzamide (CAS 611-74-5)
- 4-(Dimethylamino)-N-hydroxybenzenecarboximidamide (CAS 68451-71-8)
- 2,4,6-Trimethylpyrimidine (CAS 22114-27-8)
- N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-(ethylthio)benzamide (CAS 886918-82-7)
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- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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