Baclofen impurity 23 CAS 84803-46-3
| CAS No. | 84803-46-3 |
| Molecular Formula | C11H10ClNO2 |
| Molecular Weight | 223.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Baclofen impurity 23 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Baclofen impurity 23 (CAS 84803-46-3) is a certified pharmaceutical impurity reference standard with the molecular formula C11H10ClNO2 and a molecular weight of 223.66 g/mol.
The molecular framework of Baclofen impurity 23 (C11H10ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Baclofen impurity 23 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10ClNO2 |
| Molecular Weight | 223.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Baclofen Standards
- Baclofen Impurity 28 (CAS 70410-34-3)
- Baclofen Impurity 1 (CAS 53911-68-5)
- Baclofen Impurity 54 (CAS CATO-C4X-101254)
- Baclofen Impurity 75 (CAS CATO-C4X-101275)
- Baclofen-d4 (Major) (CAS 70155-52-1)
- Baclofen-d4 (CAS 1189938-30-4)
- Baclofen Impurity 46 (CAS CATO-C4X-101246)
- Baclofen Impurity 53 (CAS CATO-C4X-101253)
Recommended Standards
- 2306AF 5-Chloro-2-(2-furylmethoxy)aniline 893751-18-3 C11H10ClNO2 (CAS 893751-18-3)
- Gefitinib Impurity 88 (CAS CATO-C4X-111788)
- 325744-41-0 5-(chloromethyl)-3-(4-methoxyphenyl)isoxazole DTXSID50377274 (CAS 325744-41-0)
- Peridine Impurity 7 (CAS 99983-71-8)
- Cenobamate Impurity 21 (CAS CATO-C4X-241621)
- Indacaterol Impurity 15 (CAS CATO-C4X-150015)
- Quetiapine EP Impurity P (CAS 1011758-03-4)
- 1-(3-Fluoro-4-methylphenyl)-1H-pyrrole (CAS 142044-86-8)
- 3-Ethyl-3-hydroxy-2,2-dimethylpentanoic acid (CAS 27925-39-9)
- 2,4-Dimethoxyphenyl isothiocyanate (CAS 33904-03-9)
- N1-(4-methoxybenzyl)-N4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)succinamide (CAS 329700-11-0)
- Quinidine (CAS 56-54-2)
- N-[2-(5-Amino-4H-1,2,4-triazol-3-yl)ethyl]benzamide (CAS 108921-95-5)
- Semaglutide impurity 01 (CAS 1998701-31-7)
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