Neratinib Impurity N1 CAS 848139-78-6
| CAS No. | 848139-78-6 |
| Molecular Formula | C24H20ClN5O2 |
| Molecular Weight | 445.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Neratinib Impurity N1.
CATO supplies Neratinib Impurity N1 (CAS 848139-78-6), a pharmacopoeial impurity reference standard (molecular formula C24H20ClN5O2, MW 445.90 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Neratinib Impurity N1 (C24H20ClN5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 445.90 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Neratinib Impurity N1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H20ClN5O2 |
| Molecular Weight | 445.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Neratinib Standards
- Neratinib Impurity 20 (CAS CATO-C4X-113420)
- Neratinib Impurity 59 (CAS CATO-C4X-113459)
- Neratinib Impurity 2 (CAS 1144516-20-0)
- Neratinib Impurity 31 (CAS CATO-C4X-113431)
- Neratinib Impurity 50 (CAS CATO-C4X-113450)
- Neratinib Impurity N2 (CAS 915941-95-6)
- Neratinib Impurity 62 (CAS CATO-C4X-113462)
- Neratinib Impurity 14 (CAS 1144516-14-2)
Recommended Standards
- 9,9'-(6-Chloro-1,3,5-triazine-2,4-diyl)bis(9H-carbazole) (CAS 877615-05-9)
- Imatinib Impurity 87 (CAS 571187-02-5)
- 1,1,1,3,10,12,12,12-Octachlorododecane (CAS 601523-21-1)
- Avanafil Impurity 155 (CAS CATO-C4X-1118155)
- Carboplatin EP Impurity B Disilver Salt (CAS 1933502-35-2)
- Iloperidone Impurity 11 (CAS 59084-16-1)
- Brexpiprazole Impurity 110 (CAS 433303-94-7)
- 2,5-Dihydroxybiphenyl (CAS 1079-21-6)
- N-Allyl-N-(3-pyrrolidinylmethyl)-2-propen-1-aminedihydrochloride (CAS 1219960-32-3)
- 4-(tert-Butoxycarbonyl)-1-(3-methylthiophene-2-carbonyl)piperazine-2-carboxylic acid (CAS 1353944-19-0)
- cis-9 Tritetradecenoin（14:1） (CAS 99483-10-0)
- 4-(4-Methylpyridin-3-yl)butan-2-ol (CAS 1502118-52-6)
- Methyl 2-bromo-3-cyano-6-nitrobenzoate (CAS 1805520-74-4)
- [3,5 Diiodo-Tyr7] Peptide T (CAS 128551-40-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com