Ponatinib Impurity 44 (Z-Isomer) CAS CATO-C4X-226944
| CAS No. | CATO-C4X-226944 |
| Molecular Formula | C30H28F3N5O |
| Molecular Weight | 531.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 531.57 g/mol gives Ponatinib Impurity 44 (Z-Isomer) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ponatinib Impurity 44 (Z-Isomer) (CAS CATO-C4X-226944, C30H28F3N5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C30H28F3N5O, Ponatinib Impurity 44 (Z-Isomer) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 531.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H28F3N5O |
| Molecular Weight | 531.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Ponatinib Standards
- Ponatinib Impurity 43 (E-Isomer) (CAS CATO-C4X-226943)
- Ponatinib (CAS 943319-70-8)
- Ponatinib Impurity 15 (E-Isomer) (CAS CATO-C4X-226915)
- Ponatinib Impurity 18 (Z-Isomer) (CAS CATO-C4X-226918)
- Ponatinib-d8 (CAS 1562993-37-6)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Ponatinib Active Metabolite AP24567(M42) (CAS 943319-87-7)
- Ponatinib Impurity 54 (CAS CATO-C4X-226954)
Recommended Standards
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-[(4-methylphenyl)sulfonyl]-L-histidine (CAS 112380-10-6)
- Rosuvastatin Impurity 144 (CAS CATO-C4X-1169144)
- Piperacillin Methyl Ester (CAS 65700-41-6)
- Acalabrutinib Impurity 21 (CAS 2412166-56-2)
- Goserelin Impurity 53 (CAS CATO-C4X-192053)
- Betahistine Impurity 46 (CAS 1903526-05-5)
- Glibenclamide EP Impurity A (CAS 16673-34-0)
- 5-(Trifluoromethoxy)-1H-indazole-3-carboxylic Acid (CAS 869782-94-5)
- 4-Bromo-1-chloro-6-methylnaphthalene (CAS 1447449-23-1)
- 2-Cyano-N'-[(2E)-4-oxo-4-phenylbutan-2-ylidene]acetohydrazide (CAS 1086229-94-8)
- 4-chloro-1H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile (CAS 1004991-91-6)
- N2-(1-Ethylpiperidin-3-yl)pyridine-2,3-diamine (CAS 1292696-88-8)
- 3-Benzylbenzonitrile (CAS 93717-55-6)
- Semaglutide Impurity 9 (CAS CATO-C4X-22269)
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