Cabozantinib Impurity 5 CAS 849217-60-3
| CAS No. | 849217-60-3 |
| Molecular Formula | C17H15FN2O3 |
| Molecular Weight | 314.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cabozantinib Impurity 5.
As a process- or degradation-related impurity, Cabozantinib Impurity 5 (CAS 849217-60-3, C17H15FN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Cabozantinib Impurity 5 (C17H15FN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H15FN2O3 |
| Molecular Weight | 314.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Cabozantinib Standards
- Cabozantinib Impurity 3 (CAS 1431468-36-8)
- Cabozantinib Impurity 42 (CAS CATO-C4X-201842)
- Cabozantinib Impurity 8 (CAS 213699-53-7)
- Cabozantinib Impurity 48 (CAS CATO-C4X-201848)
- Cabozantinib Impurity 2 (CAS 190728-24-6)
- Cabozantinib Impurity 23 (CAS CATO-C4X-201823)
- Cabozantinib Impurity (CAS 190728-27-9)
- Cabozantinib Impurity 32 (CAS 202917-04-2)
Recommended Standards
- Sunitinib Impurity 35 (CAS CATO-C4X-133335)
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- 4,7-Diaza-spiro[2.5]octane-4-carboxylic acid benzyl ester (hydrochloride) (CAS 1951440-78-0)
- Doripenem Impurity 11 (CAS CATO-C4X-162111)
- {8-methyl-5-oxaspiro[3.5]nonan-8-yl}methanamine (CAS 2060005-87-8)
- 1,4-Bis((4-methylpentan-2-yl)amino)anthracene-9,10-dione (CAS 19720-42-4)
- 1-(tert-Butyl)-2-(5-oxo-2,5-dihydrofuran-3-yl)hydrazinecarboxylic acid (CAS 354129-82-1)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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