Trifarotene Impurity 1 CAS 850012-53-2
| CAS No. | 850012-53-2 |
| Molecular Formula | C14H20BrN |
| Molecular Weight | 282.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Trifarotene Impurity 1 (CAS 850012-53-2, C14H20BrN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Trifarotene Impurity 1 (C14H20BrN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C14H20BrN |
| Molecular Weight | 282.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Trifarotene Standards
- Trifarotene impurity 15 (CAS CATO-C4X-313215)
- Trifarotene Impurity N56 (CAS 895543-00-7)
- Trifarotene Impurity 2 (CAS 895542-84-4)
- Trifarotene impurity 27 (CAS CATO-C4X-313227)
- Trifarotene impurity 20 (CAS CATO-C4X-313220)
- Trifarotene impurity 14 (CAS CATO-C4X-313214)
- Trifarotene impurity 17 (CAS 182318-78-1)
- Trifarotene impurity 23 (CAS CATO-C4X-313223)
Recommended Standards
- Phenyl (5-(trifluoromethyl)pyridin-2-yl)carbamate (CAS 95651-19-7)
- Phenyl (4-(trifluoromethyl)pyridin-2-yl)carbamate (CAS 857265-11-3)
- Niflumic Acid (CAS 4394-00-7)
- Niflumic Acid - Impurity B (CAS 72633-64-8)
- Betaxolol EP Impurity E (CAS 1329613-85-5)
- Pidotimod impurity 6 (CAS 162148-16-5)
- Sitafloxacin impurity 55 (CAS CATO-C4X-115555)
- 2-benzyl 1-tert-butyl (2S)-5-oxo-2,5-dihydro-1H-pyrrole-1,2-dicarboxylate (CAS 879217-23-9)
- tert-Butyl 9-amino-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate (CAS 1251015-74-3)
- Fluocortolone Impurity 6 (CAS 36130-02-6)
- 2-(2-Amino-5-chloro-6-(difluoromethyl)pyridin-3-yl)acetonitrile (CAS 1805060-56-3)
- (2,5-Difluoropyridin-3-yl)methanol (CAS 1227588-79-5)
- 2-(Cyclohexylamino)butan-1-ol (CAS 51977-19-6)
- D-Pro38-Tirzepatide (CAS CATO-CPTD788901)
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