Trifarotene Impurity 2 CAS 895542-84-4
| CAS No. | 895542-84-4 |
| Molecular Formula | C15H13BrO3 |
| Molecular Weight | 321.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Trifarotene Impurity 2 (CAS 895542-84-4, C15H13BrO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Trifarotene Impurity 2 (C15H13BrO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Trifarotene Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13BrO3 |
| Molecular Weight | 321.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
Related Trifarotene Standards
- Trifarotene impurity 27 (CAS CATO-C4X-313227)
- Trifarotene impurity 20 (CAS CATO-C4X-313220)
- Trifarotene Impurity 1 (CAS 850012-53-2)
- Trifarotene impurity 15 (CAS CATO-C4X-313215)
- Trifarotene impurity 23 (CAS CATO-C4X-313223)
- Trifarotene impurity 21 (CAS CATO-C4X-313221)
- Trifarotene impurity 26 (CAS CATO-C4X-313226)
- Trifarotene Impurity N56 (CAS 895543-00-7)
Recommended Standards
- Roxadustat Impurity 162 (CAS CATO-C4X-2213162)
- Tert-butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)carbamate (CAS 1032758-88-5)
- 938153-97-0 5-Bromo-2-[(2-methylbenzyl)oxy]benzoic acid MFCD09707674 (CAS 938153-97-0)
- 2-(5-Isopropoxy-2-methyl-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1032903-51-7)
- Xanomeline impurity 30 (CAS CATO-C4X-330130)
- Cabergoline Impurity 49 (CAS CATO-C4X-27749)
- Triptorelin Impurity 9 (CAS CATO-C4X-18629)
- 6-(4-Fluorophenoxy)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 343372-96-3)
- 6-(((4,6-Dimethylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-chlorobenzoate (CAS 877635-63-7)
- Benzoyloxypaeoniflorin (CAS 72896-40-3)
- 1,1,1-Triethoxy-3-methylbutane (CAS 55048-55-0)
- 53655-17-7 5-Chloro-2-(2-(3-((5-chloro-3-ethyl-3H-benzothiazol-2-ylidene)ethylidene)-2-(diphenylamino)cyclopent-1-en-1-yl)vinyl)-3-ethylbenzothiazolium perchlorate Benzothiazolium, 5-chloro-2-(2-(3-(2-(5-chloro-3-ethyl-2(3H)-benzothiazolylidene)ethylidene)-2-(diphenylamino)-1-cyclopenten-1-yl)ethenyl)-3-ethyl-, perchlorate (1:1) Benzothiazolium, 5-chloro-2-(2-(3-((5-chloro-3-ethyl-2(3H)-benzothiazolylidene)ethylidene)-2-(diphenylamino)-1-cyclopenten-1-yl)ethenyl)-3-ethyl-, perchlorate EINECS 258-689-0 IR 140 Kodak IR 140 NSC 290436 (CAS 53655-17-7)
- 4-(2-(2-(2-Methoxyethoxy)ethoxy)ethyl)piperidine (CAS 1220178-01-7)
- Semaglutide Impurity 6 (CAS 62-57-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com