Palbociclib Impurity 72 CAS 850918-83-1
| CAS No. | 850918-83-1 |
| Molecular Formula | C22H26BrN7O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Palbociclib Impurity 72 (CAS 850918-83-1, C22H26BrN7OHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H26BrN7OHCl, Palbociclib Impurity 72 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 520.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Palbociclib Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26BrN7O HCl |
| Molecular Weight | 520.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 7 |
Related Palbociclib Standards
- Palbociclib Impurity 96 (CAS 1013916-37-4)
- Palbociclib Impurity 25 (CAS 1016636-76-2)
- Palbociclib Impurity 6 (CAS 1023594-49-1)
- Palbociclib Impurity 26 (CAS 1023594-50-4)
- Palbociclib Impurity 2 (CAS 1072-97-5)
- Palbociclib Impurity 32 (CAS 1082876-26-3)
- Palbociclib Impurity 204 (CAS 119285-06-2（free base）)
- Palbociclib Impurity 208 (CAS 120613-50-5)
Recommended Standards
- Emedastine EP Impurity C DiHCl (CAS CATO-C4X-226722)
- Moxifloxacin Impurity 44 (CAS 112811-70-8)
- Pentoxifylline Impurity 25 (CAS 57987-84-5)
- Ethyl 4-(3-Aminophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate (CAS 138135-48-5)
- N-Nitroso Melphalan EP Impurity K (CAS 55-18-5)
- 5-Methoxy-2-methyl-4-nitrobenzo[d]thiazole (CAS 265312-58-1)
- 3-(4-Formyl-3-methyl-1h-pyrazol-1-yl)propanenitrile (CAS 372190-37-9)
- 1-(3-(Trifluoromethyl)cyclohexyl)ethan-1-amine (CAS 1560300-11-9)
- 2-Bromo-1H-indole-6-carboxylic acid (CAS 1782429-68-8)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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