Penicillamine Impurity 1 CAS 856846-79-2
| CAS No. | 856846-79-2 |
| Molecular Formula | C11H11N3O2 |
| Molecular Weight | 217.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 217.22 g/mol gives Penicillamine Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Penicillamine Impurity 1 (CAS 856846-79-2, C11H11N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H11N3O2, Penicillamine Impurity 1 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 217.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Penicillamine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H11N3O2 |
| Molecular Weight | 217.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 3 |
Related Penicillamine Standards
- Penicillamine impurity 3 (CAS CATO-C4X-29233)
- Penicillamine Impurity 2 (CAS CATO-CP155169)
- L-Penicillamine-d6 (CAS 1795786-79-6)
- D-Penicillamine-d3 (CAS CATO-C4X-29234)
- L-Penicillamine (CAS 1113-41-3)
- D-Penicillamine (CAS 52-67-5)
- DL-Penicillamine disulfide (CAS 312-10-7)
- Penicillamine EP Impurity A (CAS 20902-45-8)
Recommended Standards
- Antipyrine Impurity 2 (CAS 885-11-0)
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- Pirfenidone Impurity 22 (CAS CATO-C4X-222922)
- Ivacaftor Impurity 9 (CAS 26892-90-0)
- Finerenone Impurity 288 (CAS CATO-C4X-2880288)
- Rimegepant Impurity 91 (CAS CATO-C4X-248791)
- Atosiban Impurity 60 (CAS CATO-C4X-229360)
- 6-Methyl-1,2,3,4-tetrahydroquinoline hydrochloride (CAS 1431964-04-3)
- (R)-3-((tert-Butoxycarbonyl)amino)-5-methylhexanoic Acid (CAS 146398-18-7)
- 5-Isopropylnicotinimidamide (CAS 1256785-76-8)
- 4-Amino-2-methylthiochroman 1,1-dioxide (CAS 1153828-50-2)
- N-((1H-Benzo[d][1,2,3]triazol-1-yl)methyl)benzothioamide (CAS 117067-55-7)
- N-{3-[(2-Bromoacetyl)amino]phenyl}-4-(tert-butyl)benzamide (CAS 1138443-10-3)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
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