Bortezomib Impurity 4 CAS 289472-81-7
| CAS No. | 289472-81-7 |
| Molecular Formula | C19H24N4O3 |
| Molecular Weight | 356.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Bortezomib Impurity 4 (CAS 289472-81-7) is a certified pharmaceutical impurity reference standard with the molecular formula C19H24N4O3 and a molecular weight of 356.42 g/mol.
Based on its molecular formula C19H24N4O3, Bortezomib Impurity 4 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 356.42 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Bortezomib Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H24N4O3 |
| Molecular Weight | 356.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 4 |
Related Bortezomib Standards
- Bortezomib Impurity 3 (CAS 289472-78-2)
- Bortezomib Impurity 20 (CAS 862894-96-0)
- Bortezomib Impurity 15 (CAS 275374-67-9)
- Bortezomib Impurity 19 (CAS CATO-C4X-107219)
- Bortezomib Impurity 30 (CAS 2379402-85-2)
- Bortezomib Impurity 52 (CAS CATO-C4X-107252)
- Bortezomib Impurity 65 (CAS CATO-C4X-107265)
- Bortezomib Impurity 13 (CAS 1446194-56-4)
Recommended Standards
- Indobufen Impurity 57 (CAS CATO-C4X-179257)
- 99694-90-3 Methyl (19S)-12,19-dihydroxy-2,16-didehydrocuran-17-oate (CAS 99694-90-3)
- Otilonium Bromide Impurity 4 (CAS 1007652-84-7)
- 1-benzyl-N-(4-methoxyphenyl)-1H-indole-3-carboxamide 860611-44-5 KS-00002YJ3 (CAS 860611-44-5)
- Esaxerenone Impurity 6 (CAS CATO-C4X-34486)
- Metoclopramide Impurity 28 (CAS 20896-27-9)
- Indazole Impurity 3 (CAS 1801267-04-8)
- 3-((2-Hydroxy-3-methoxybenzyl)amino)-1H-pyrazole-4-carbonitrile (CAS 1027754-56-8)
- Cirsimarin (CAS 13020-19-4)
- Furan-2-yl(thiophen-3-yl)methanol (CAS 136260-85-0)
- Macitentan Impurity 1 (CAS 441798-25-0)
- 3-Chloro-4-(hydroxymethyl)phenylboronic Acid (CAS 1190875-60-5)
- rel-(1R,3S)-3-(2-Methoxyethoxy)cyclopentan-1-amine (CAS 2808310-23-6)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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