Dasatinib Monohydrate CAS 863127-77-9
| CAS No. | 863127-77-9 |
| Molecular Formula | C22H26ClN7O2S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dasatinib Monohydrate is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dasatinib Monohydrate (CAS 863127-77-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H26ClN7O2SH2O and a molecular weight of 506.02 g/mol.
Dasatinib Monohydrate (C22H26ClN7O2SH2O) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dasatinib Monohydrate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H26ClN7O2S H2O |
| Molecular Weight | 506.02 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
Recommended Standards
- Fluticasone Furoate Impurity 1 (CAS CATO-C4X-32541)
- Tretinoin EP Impurity F (4-Methoxy Retinoic Acid) (CAS 81121-20-2)
- Agomelatine impurity 31 (CAS CATO-C4X-110831)
- 4-[(2,2,2-trifluoroethyl)sulfamoyl]benzene-1-sulfonyl chloride (CAS 1036475-80-5)
- 2-Benzimidazolylurea (CAS 24370-25-0)
- {imidazo[1,2-a]pyridin-3-ylmethyl}trimethylazanium iodide (CAS 2717-91-1)
- Ethyl 3-bromo-5,7-dimethylimidazo[1,2-a]pyrimidine-2-carboxylate (CAS 1524188-84-8)
- 2-[(4-Fluorophenyl)methyl]-6-[(E)-2-phenylethenyl]-2,3,4,5-tetrahydropyridazin-3-one (CAS 303146-74-9)
- 3-(5-Methylfuran-2-yl)thiomorpholine (CAS 1344306-84-8)
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
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