Sertraline Impurity 1 CAS 866018-46-4
| CAS No. | 866018-46-4 |
| Molecular Formula | C16H14Cl2O |
| Molecular Weight | 293.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sertraline Impurity 1 is closely related to a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Sertraline Impurity 1 (CAS 866018-46-4), molecular formula C16H14Cl2O and molecular weight 293.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Sertraline Impurity 1 (C16H14Cl2O) is characterized by a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Sertraline Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H14Cl2O |
| Molecular Weight | 293.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Sertraline Standards
- Sertraline RC 6 (Base) (CAS 755752-66-0)
- Sertraline EP Impurity F Enantiomer (CAS 124379-29-9)
- Sertraline Impurity N1 (CAS 152448-80-1)
- rac-Sertraline EP Impurity F (CAS 79560-19-3)
- Sertraline EP Impurity F (CAS 155748-61-1)
- Sertraline Impurity 66 (CAS CATO-C4X-134466)
- Sertraline Impurity 68 (CAS CATO-C4X-134468)
- Sertraline Impurity 72 (CAS CATO-C4X-134472)
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