2-[3-(Hydroxymethyl)piperidino]-5-[(E)-1-naphthylmethylidene]-1,3-thiazol-4(5H)-one CAS 866149-74-8
| CAS No. | 866149-74-8 |
| Molecular Formula | C20H20N2O2S |
| Molecular Weight | 352.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-[3-(Hydroxymethyl)piperidino]-5-[(E)-1-naphthylmethylidene]-1,3-thiazol-4(5H)-one (CAS 866149-74-8), molecular formula C20H20N2O2S and molecular weight 352.45 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, 2-[3-(Hydroxymethyl)piperidino]-5-[(E)-1-naphthylmethylidene]-1,3-thiazol-4(5H)-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 352.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H20N2O2S |
| Molecular Weight | 352.45 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Hydroxymethyl Standards
- [4-(Hydroxymethyl)-1-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]-1H-1,2,3-triazol-5-yl]methanol (CAS 861210-55-1)
- 4-Butyl-4-(hydroxymethyl)-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione (CAS 84803-48-5)
- Methyl 2-((4-(hydroxymethyl)-1-methyl-3-phenyl-1H-pyrazol-5-yl)thio)benzoate (CAS 318234-06-9)
- (3-((2-(Hydroxymethyl)phenyl)dimethylsilyl)phenyl)(morpholino)methanone (CAS 1244855-69-3)
- (4-((2-(Hydroxymethyl)phenyl)dimethylsilyl)phenyl)(morpholino)methanone (CAS 1244855-81-9)
- Methyl 4-(((5-(hydroxymethyl)-1-(2-(methylamino)-2-oxoethyl)-1H-imidazol-2-yl)thio)methyl)benzoate (CAS 923677-52-5)
- rac 5-Hydroxymethyl Tolterodine-d14 (CAS 1185071-13-9)
- 2-((5-(Hydroxymethyl)-1-(2-(methylamino)-2-oxoethyl)-1H-imidazol-2-yl)thio)-N-(m-tolyl)acetamide (CAS 923195-18-0)
Recommended Standards
- 2-(Piperidin-1-yl)-5-(piperidine-1-sulfonyl)benzoic acid (CAS 37093-37-1)
- 2-Phenoxy-N-(2-(2-(p-tolyl)thiazol-4-yl)ethyl)acetamide (CAS 896614-39-4)
- 2-(Benzylsulfonyl)-1,1-diphenylethan-1-ol (CAS 251307-46-7)
- 3,5-Bis(4-methoxybenzylidene)dihydro-2H-thiopyran-4(3H)-one (CAS 61448-77-9)
- Methyl 2-amino-4-(4-(methoxycarbonyl)phenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate (CAS 329057-46-7)
- (S)-1-(2-(Methylamino)benzoyl)pyrrolidine-2-carboxylic acid (CAS 58177-15-4)
- 3-O-tert-butyldimethylsilyl-4,6-o-benzylidene-d-glucal (CAS 120120-65-2)
- Tert-butyl 3-(3,3,3-trifluoro-2-hydroxypropyl)piperidine-1-carboxylate (CAS 1228631-22-8)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(2-chlorophenyl)acetic acid (CAS 1260608-83-0)
- n-(4-Morpholinophenyl)isobutyramide (CAS 250714-61-5)
- Methyl 2-amino-2-(naphthalen-1-yl)acetate hydrochloride (CAS 13227-00-4)
- 2-(3-(4-Methoxyphenyl)-1H-pyrazol-1-yl)acetic acid (CAS 959584-25-9)
- 2-(trifluoromethoxy)aniline hydrochloride (CAS 452077-64-4)
- Tirzepatide (CAS 2023788-19-2)
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