Phloroglucinol EP Impurity I CAS 87-65-0
| CAS No. | 87-65-0 |
| Molecular Formula | C6H4Cl2O |
| Molecular Weight | 163.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 163.00 g/mol gives Phloroglucinol EP Impurity I distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Phloroglucinol EP Impurity I (CAS 87-65-0), a pharmacopoeial impurity reference standard (molecular formula C6H4Cl2O, MW 163.00 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C6H4Cl2O, Phloroglucinol EP Impurity I contains a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 163.00 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Phloroglucinol EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4Cl2O |
| Molecular Weight | 163.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Phloroglucinol Standards
- Phloroglucinol Dihydrate EP Impurity L (CAS 626-43-7)
- Phloroglucinol Impurity 36 (CAS 530-55-2)
- Phloroglucinol Impurity 32 (CAS 83-30-7)
- Phloroglucinol Impurity 31 (CAS 1664-27-3)
- Phloroglucinol Impurity 28 (CAS 500-99-2)
- Phloroglucinol Impurity 22 (CAS 106-40-1)
- Phloroglucinol Impurity 14 (CAS 7051-16-3)
- Phloroglucinol Impurity 15 (CAS 95-56-7)
Recommended Standards
- Dasatinib Impurity 42 (CAS 1780-26-3)
- 3-Amino-2,6-dichloropyridine (CAS 62476-56-6)
- Roflumilast USP Related Compound C (CAS 22889-78-7)
- 2,4-dichlorophenol-cp std (CAS 120-83-2)
- Finerenone Impurity 114 (CAS CATO-C4X-2880114)
- Eugenol Impurity 11 (CAS CATO-C4X-198911)
- Pretomanid Impurity 19 (CAS CATO-C4X-260619)
- 6-Methyl-2,3-dihydro-1-benzothiophen-3-one (CAS 68670-98-4)
- (S)-1-tert-Butyl 2-methyl 5-oxopiperidine-1,2-dicarboxylate (CAS 915976-31-7)
- 3-Chloro-2,2-dimethyl-N-[4-(trifluoromethoxy)phenyl]propanamide (CAS 341965-83-1)
- N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-((4-phenyl-5-((p-tolylamino)methyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 333313-72-7)
- Methyl ((S)-1-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate (CAS 1228552-27-9)
- 4-Ethylpiperidin-4-amine dihydrochloride (CAS 1774896-82-0)
- Semaglutide Impurity 186 (CAS CATO-C4X-2226186)
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