Aripiprazole Impurity N9 CAS 870765-38-1
| CAS No. | 870765-38-1 |
| Molecular Formula | C14H20Cl2N2O |
| Molecular Weight | 303.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Aripiprazole Impurity N9 (CAS 870765-38-1, C14H20Cl2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Aripiprazole Impurity N9 (C14H20Cl2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H20Cl2N2O |
| Molecular Weight | 303.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Aripiprazole Standards
- Aripiprazole Impurity 3 (CAS 129722-34-5)
- Aripiprazole Impurity 61 (CAS 63309-35-3)
- Aripiprazole Impurity 64 (CAS 63136-84-5)
- Aripiprazole N-Bromobutyl Impurity (CAS 1424857-68-0)
- Aripiprazole Impurity 71 (CAS CATO-C4X-100871)
- Aripiprazole Impurity 21 (CAS 2250243-33-3)
- Aripiprazole Impurity 48 (CAS 1424857-93-1)
- Aripiprazole Impurity 38 (CAS CATO-C4X-100838)
Recommended Standards
- Bumetanide Impurity 65 (CAS CATO-C4X-198665)
- Methyl 2-(1,3-dimethyl-6-oxo-4-(trifluoromethyl)-1,6-dihydro-7h-pyrazolo[3,4-b]pyridin-7-yl)acetate (CAS 1018051-93-8)
- Pomalidomide Impurity 11 (CAS 19171-18-7)
- 3-[2-ethyl-6-oxo-4-(trifluoromethyl)-2h,6h,7h-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid (CAS 1018126-93-6)
- Landiolol Impurity 78 (CAS CATO-C4X-262178)
- Rimegepant Impurity 48 (CAS CATO-C4X-248748)
- Selexipag Impurity 60 (CAS CATO-C4X-196160)
- 1-((4-Chlorophenyl)sulfonyl)-4-(2-fluoro-4-nitrophenyl)piperazine (CAS 866131-33-1)
- Osthole (CAS 484-12-8)
- 2-(4-Methylthiazol-2-yl)ethanol (CAS 333385-00-5)
- (S)-2-((S)-2,6-Diaminohexanamido)-3-methylbutanoic acid hydrochloride (CAS 92218-55-8)
- (6-(Dimethylamino)-4-isopropoxypyridin-3-yl)boronic acid (CAS 848947-78-4)
- 3-(1-hydroxycyclobutyl)propanenitrile (CAS 1909327-55-4)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
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