Aripiprazole Impurity 21 CAS 2250243-33-3
| CAS No. | 2250243-33-3 |
| Molecular Formula | C12H13Cl2NO3 |
| Molecular Weight | 290.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 290.14 g/mol gives Aripiprazole Impurity 21 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Aripiprazole Impurity 21 (CAS 2250243-33-3, C12H13Cl2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Aripiprazole Impurity 21 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 290.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13Cl2NO3 |
| Molecular Weight | 290.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Aripiprazole Standards
- Aripiprazole Impurity 71 (CAS CATO-C4X-100871)
- Aripiprazole Impurity 48 (CAS 1424857-93-1)
- Aripiprazole-Impurity 10 (CAS 82657-32-7)
- Aripiprazole Impurity 3 (CAS 129722-34-5)
- Aripiprazole Impurity 61 (CAS 63309-35-3)
- Aripiprazole Impurity 64 (CAS 63136-84-5)
- Aripiprazole N-Bromobutyl Impurity (CAS 1424857-68-0)
- Aripiprazole Impurity N9 (CAS 870765-38-1)
Recommended Standards
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