Itraconazole Impurity 12 CAS 67914-84-5

Purity 97%+In StockPharmaceutical Standards
CAS No.67914-84-5
Molecular FormulaC20H17Cl2N3O4
Molecular Weight434.27 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

Itraconazole Impurity 12 CAS 67914-84-5 chemical structure

Description

CATO manufactures Itraconazole Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Itraconazole Impurity 12 (CAS 67914-84-5), molecular formula C20H17Cl2N3O4 and molecular weight 434.27 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Itraconazole Impurity 12 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 434.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

Physical & Chemical Properties

Molecular FormulaC20H17Cl2N3O4
Molecular Weight434.27 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore in a cool place (≤25°C), protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)13.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1976
Halogen ContentCl-containing
Nitrogen Atoms3

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