2-Chloro-4-(difluoromethoxy)phenol CAS 88798-11-2
| CAS No. | 88798-11-2 |
| Molecular Formula | C7H5ClF2O2 |
| Molecular Weight | 194.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Chloro-4-(difluoromethoxy)phenol (CAS 88798-11-2) is a high-purity analytical reference standard with the molecular formula C7H5ClF2O2 and a molecular weight of 194.56 g/mol.
The molecular framework of 2-Chloro-4-(difluoromethoxy)phenol (C7H5ClF2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures 2-Chloro-4-(difluoromethoxy)phenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF2O2 |
| Molecular Weight | 194.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-Chloro-3-(difluoromethoxy)phenol (CAS 1261440-11-2)
- 2-Chloro-3-(difluoromethoxy)phenol (CAS 1261478-68-5)
- 3-Chloro-4-(difluoromethoxy)phenol (CAS 1261604-72-1)
- 6-Chloro-4-(difluoromethoxy)pyridin-2-amine (CAS 1677685-18-5)
- 2-Chloro-6-(difluoromethyl)pyrimidine-4,5-diamine (CAS 1706444-59-8)
- 5-Chloro-6-(difluoromethyl)-2-methylpyrimidin-4(3H)-one (CAS 1707378-61-7)
- 2-Chloro-5-(difluoromethoxy)-4-methylpyrimidine (CAS 1823916-35-3)
- 2-Chloro-2-oxoethane-1,1-diyl diacetate (CAS 36674-73-4)
Recommended Standards
- 3-(2-Chloroethoxy)-1,1,2,2-tetrafluoropropane (CAS 64769-39-7)
- Lasmiditan Impurity 1 (CAS 79538-29-7)
- 2,4,5-trifluorobenzoylchloride (CAS 88419-56-1)
- 6-Amino-2-chloro-5-(difluoromethyl)pyridin-3-ol (CAS 1803670-69-0)
- 2-(3,4-Dimethoxybenzylidene)-1H-indene-1,3(2H)-dione (CAS 58161-74-3)
- Fmoc-Gly-Pro-OH (CAS 212651-48-4)
- [2-(2-Methoxy-ethoxy)-ethyl]-methyl-amine (CAS 124192-94-5)
- 1-(Furan-2-ylmethyl)pyrrolidin-3-amine (CAS 939759-93-0)
- 2-(5-Ethylthiophen-2-yl)-6-methylquinoline-4-carboxylic acid (CAS 438216-59-2)
- N-(1,1-Dioxothiepan-4-yl)-1-ethyl-indazol-6-amine (CAS 2798391-55-4)
- (3-Methoxyphenyl)(triphenylphosphine)gold (CAS 870485-34-0)
- 5,6,7,8-Tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (CAS 345311-09-3)
- 1-Benzyl-4-(5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 402946-95-6)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com