Nitrendipine EP Impurity A CAS 89267-41-4
| CAS No. | 89267-41-4 |
| Molecular Formula | C18H18N2O6 |
| Molecular Weight | 358.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nitrendipine EP Impurity A (CAS 89267-41-4, C18H18N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nitrendipine EP Impurity A (C18H18N2O6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18N2O6 |
| Molecular Weight | 358.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Nitrogen Atoms | 2 |
Related Nitrendipine Standards
- Nitrendipine Impurity 2 (CAS CATO-C4X-18342)
- (+)-Nitrendipine (CAS 80890-07-9)
- Nitrendipine (CAS 39562-70-4)
- Nitrendipine-d5 (CAS 2469554-26-3)
- Nitrendipine Impurity 5 (CAS 74936-73-5)
- Nitrendipine impurity 21 (CAS 1195583-65-3)
- Nitrendipine Impurity 3 (CAS 76258-20-3)
- Nitrendipine Impurity 7 (CAS 89267-42-5)
Recommended Standards
- Riboflavin Impurity 28 (CAS CATO-C4X-181928)
- Epinephrine /Adrenaline Impurity 134 (CAS CATO-C4X-1849134)
- Riboflavin Impurity 26 (CAS CATO-C4X-181926)
- 4,4'-Bismaleimidodiphenylmethane (CAS 13676-54-5)
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- Zolmitriptan Impurity 6 (CAS 1241387-63-2)
- Aprepitant Impurity 71 (CAS CATO-C4X-114171)
- Piperidin-2-yl(thiomorpholino)methanone (CAS 1218531-53-3)
- 1-(2’-Deoxy-3’,5’-di-O-toluoyl-a,b-D-ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3,5-triazine (CAS 1442660-61-8)
- 3-(Benzyloxy)picolinonitrile (CAS 24059-90-3)
- 2-((Piperidin-4-ylmethyl)thio)pyridine (CAS 794464-04-3)
- 2,3,4-Trimethyl-2-cyclopentenone (CAS 28790-86-5)
- 3-(4-Methoxyphenyl)-1-(p-tolyl)-1H-pyrazole-4-carbaldehyde (CAS 618098-46-7)
- Liraglutide (14-31)TFA Salt (CAS CATO-C4X-19927)
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