2-Chloro-5-(3-(trifluoromethyl)benzamido)benzoic acid CAS 896160-35-3
| CAS No. | 896160-35-3 |
| Molecular Formula | C15H9ClF3NO3 |
| Molecular Weight | 343.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Chloro-5-(3-(trifluoromethyl)benzamido)benzoic acid (C15H9ClF3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-Chloro-5-(3-(trifluoromethyl)benzamido)benzoic acid (CAS 896160-35-3), a certified reference material (molecular formula C15H9ClF3NO3, MW 343.69 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H9ClF3NO3 |
| Molecular Weight | 343.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- (E)-2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazono)methyl)benzoic acid (CAS 338795-35-0)
- 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-6-methyl-4-oxo-1,4-dihydropyrimidine-5-carbonitrile (CAS 303153-05-1)
- 4-(3-Chloro-4-fluorophenoxy)-6-nitroquinoline-3-carbonitrile (CAS 928779-54-8)
- N-(4-Chloro-3-nitrophenyl)-2-indol-3-yl-2-oxoethanamide (CAS 1024255-49-9)
- 5-[(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]-2-hydroxybenzoic acid (CAS 500301-76-8)
- 2-Chloro-4-(thiazol-5-yl)phenyl trifluoromethanesulfonate (CAS 1823433-21-1)
- 1-(2-Chloro-5-(trifluoromethyl)phenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine (CAS 351468-83-2)
- 1-Benzyl-3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}urea (CAS 326816-47-1)
Recommended Standards
- N'-[(6-chloropyridin-3-yl)carbonyl]-4-(trifluoromethyl)benzohydrazide (CAS 263563-39-9)
- (E)-{amino[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylidene}amino benzoate (CAS 338791-59-6)
- 5-(1,3-Dimethyl-1h-pyrazol-4-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride (CAS 1006481-23-7)
- 1,3-diethyl 2-(2-chloro-4-nitrobenzoyl)propanedioate (CAS 1443979-57-4)
- 2-Cyclopropylpentanoic acid (CAS 1553896-27-7)
- 959238-90-5 2-Methoxy-N-methyl-1-(pyridin-2-yl)ethan-1-amine DTXSID50672433 (CAS 959238-90-5)
- 2-(Methylsulfonamido)aniline (CAS 37073-18-0)
- 8-Methyl-4-(2-phenylbutanoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326812-71-8)
- 4-(2-Fluoro-3-nitrophenyl)pyridine (CAS 1214391-68-0)
- Mexiletine EP Impurity D HCl (CAS CATO-C4X-19298)
- Methyl 2-(hydroxymethyl)acrylate (CAS 15484-46-5)
- 2-((4-Nitrobenzylidene)amino)-4,5-diphenylfuran-3-carbonitrile (CAS 18031-67-9)
- 2-(Chloromethyl)-5-cyano-3-(difluoromethyl)-4-nitropyridine (CAS 1807164-67-5)
- Semaglutide impurity 70 (CAS CATO-C4X-222670)
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