(E)-2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazono)methyl)benzoic acid CAS 338795-35-0
| CAS No. | 338795-35-0 |
| Molecular Formula | C14H9ClF3N3O2 |
| Molecular Weight | 343.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (E)-2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazono)methyl)benzoic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(E)-2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazono)methyl)benzoic acid (CAS 338795-35-0), molecular formula C14H9ClF3N3O2 and molecular weight 343.69 g/mol, is a CATO reference standard with documented purity and traceability.
(E)-2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazono)methyl)benzoic acid (C14H9ClF3N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazono)methyl)benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9ClF3N3O2 |
| Molecular Weight | 343.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
- 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-6-methyl-4-oxo-1,4-dihydropyrimidine-5-carbonitrile (CAS 303153-05-1)
- 2-Chloro-5-(3-(trifluoromethyl)benzamido)benzoic acid (CAS 896160-35-3)
- 4-(3-Chloro-4-fluorophenoxy)-6-nitroquinoline-3-carbonitrile (CAS 928779-54-8)
- N-(4-Chloro-3-nitrophenyl)-2-indol-3-yl-2-oxoethanamide (CAS 1024255-49-9)
- 5-[(3-Chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino]-2-hydroxybenzoic acid (CAS 500301-76-8)
- 2-Chloro-4-(thiazol-5-yl)phenyl trifluoromethanesulfonate (CAS 1823433-21-1)
- 1-(2-Chloro-5-(trifluoromethyl)phenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine (CAS 351468-83-2)
- 1-Benzyl-3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}urea (CAS 326816-47-1)
Recommended Standards
- (E)-{amino[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methylidene}amino benzoate (CAS 338791-59-6)
- 5-(1,3-Dimethyl-1h-pyrazol-4-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl chloride (CAS 1006481-23-7)
- Octachlorocyclopentene (CAS 706-78-5)
- N'-[(6-chloropyridin-3-yl)carbonyl]-4-(trifluoromethyl)benzohydrazide (CAS 263563-39-9)
- 4-(Hydroxymethyl)-2-methoxy-5-nitrophenol (CAS 260417-00-3)
- 4-Chloro-6-{4-[5-(furan-2-yl)-1H-pyrazol-3-yl]piperidin-1-yl}pyrimidin-2-amine (CAS 1026080-38-5)
- 3-Bromo-5-(methoxymethyl)benzonitrile (CAS 1383985-28-1)
- tert-Butyl 4-iodo-1H-pyrazole-3-carboxylate (CAS 1354704-09-8)
- Benzyl (6-bromobenzo[b]thiophen-2-yl)carbamate (CAS 2570190-27-9)
- 1-(bromomethyl)-2-chloro-5-fluoro-4-nitrobenzene (CAS 1299488-14-4)
- 1,1,1-trifluoro-2-methyl-3-(4-{1H-pyrrolo[2,3-b]pyridin-3-yl}piperidin-1-yl)propan-2-ol (CAS 2430373-06-9)
- 3-(Difluoromethyl)-1-isopropyl-1H-pyrazol-5-ol (CAS 1565935-75-2)
- Valsartan Impurity 57 (CAS 1353844-77-5)
- Semaglutide Impurity 155 (x TFA Salt) (CAS CATO-C4X-2226155)
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