Itraconazole Impurity 46 CAS 89848-54-4
| CAS No. | 89848-54-4 |
| Molecular Formula | 2*C34H34Cl2N8O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Itraconazole Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Itraconazole Impurity 46 (CAS 89848-54-4), a pharmacopoeial impurity reference standard (molecular formula C34H34Cl2N8O4, MW 689.60 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Itraconazole Impurity 46 (C34H34Cl2N8O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | 2*C34H34Cl2N8O4 |
| Molecular Weight | 689.60 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Itraconazole Standards
- Itraconazole Impurity 44 (CAS 103661-14-9)
- Itraconazole Impurity 41 (CAS 106461-41-0)
- Itraconazole Impurity 93 (CAS 110762-98-6)
- Itraconazole 2-Oxo Metabolite (CAS 112560-33-5)
- Itraconazole Impurity 38 (CAS 115897-54-6)
- Itraconazole N-Formyl-Ethlene Impurity (CAS 1199350-00-9)
- Itraconazole Impurity 73 (CAS 1199350-02-1)
- Itraconazole-d5(major) (CAS 1217510-38-7)
Recommended Standards
- Tenofovir disoproxil Impurity 3 (CAS 52364-31-5)
- Empagliflozin Impurity 2 (CAS 2517968-35-1)
- Irsogladine Impurity 7 (CAS CATO-C4X-29147)
- 4-Methoxypent-3-en-2-one (CAS 2845-83-2)
- Propan-2-yl 3-bromo-4-iodo-5-methylbenzoate (CAS 2364585-31-7)
- methyl 6-methylthieno[3,2-d]pyrimidine-4-carboxylate (CAS 2306269-09-8)
- 3-(4-(4-(Dimethylamino)styryl)pyridin-1-ium-1-yl)propane-1-sulfonate (CAS 131032-72-9)
- (1H-Indol-1-yl)(2-methoxyphenyl)methanone (CAS 820234-17-1)
- 1-Methylfluorene (CAS 1730-37-6)
- Tau Peptide (304-318) trifluoroacetate salt (CAS 330456-49-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com