Amphotericin B Impurity 2(N-Acetyl Amphotericin B) CAS 902457-23-2
| CAS No. | 902457-23-2 |
| Molecular Formula | C49H75NO18 |
| Molecular Weight | 966.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Amphotericin B Impurity 2(N-Acetyl Amphotericin B) (CAS 902457-23-2, C49H75NO18) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Amphotericin B Impurity 2(N-Acetyl Amphotericin B) (C49H75NO18) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C49H75NO18 |
| Molecular Weight | 966.12 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Amphotericin Standards
- Amphotericin B Impurity 30 (CAS 136135-61-0)
- Amphotericin B Ethyl Ester (CAS 55298-62-9)
- Amphotericin B Impurity 27 (CAS CATO-C4X-184427)
- Amphotericin B EP Impurity C (CAS CATO-C4X-18444)
- Amphotericin B ChP Impurity E (CAS CATO-C4X-184414)
- Amphotericin B Impurity 28 (CAS CATO-C4X-184428)
- Amphotericin B Impurity 8 (CAS CATO-C4X-18448)
- Amphotericin Impurity 9 (CAS CATO-C4X-18449)
Recommended Standards
- 149471-11-4 Neuropeptide DF2 L-Phenylalaninamide, L-alpha-aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl- Asp-arg-asn-phe-leu-arg-phe-NH2 Aspartyl-arginyl-asparaginyl-phenylalanyl-leucyl-arginyl-phenylalaninamide L-alpha-Aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl-L-phenylalaninamide DF(2) Neuropeptide Drnflrfamide (CAS 149471-11-4)
- [D-Tyr2]-Atosiban (CAS CATO-C4X-229344)
- H-Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-NH2 (CAS 110590-61-9)
- (Ser4,Ile8)-Oxytocin (CAS 550-21-0)
- Labetalol EP Impurity D HCl (CAS 32780-65-7)
- Dabrafenib Impurity 8 (CAS 686258-75-3)
- Metoclopramide Impurity 24 (CAS CATO-C4X-141524)
- 2-Chloro-3-hydroxyisonicotinaldehyde (CAS 1196145-81-9)
- 1-Phenyl-3-(5-sulfanyl-1,3,4-thiadiazol-2-yl)urea (CAS 31199-89-0)
- 3H-Indolium, 2-[2-[4-[(2-cyanoethyl)ethylamino]-2-methylphenyl]ethenyl]-1,3,3-trimethyl-, phosphate (CAS 72208-20-9)
- 2-(2-Oxo-3-phenyl-1,4-diazaspiro[4.4]non-3-en-1-yl)acetic acid (CAS 1710195-67-7)
- rac-Avocadene (CAS 83797-45-9)
- Ethyl 4-chloropyrrolo[1,2-a]quinoxaline-6-carboxylate (CAS 1255927-18-4)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
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