Progesterone Impurity 53 CAS 903-03-7
| CAS No. | 903-03-7 |
| Molecular Formula | C22H32O2 |
| Molecular Weight | 328.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Progesterone Impurity 53 (CAS 903-03-7, C22H32O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C22H32O2, Progesterone Impurity 53 contains a steroid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 328.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C22H32O2 |
| Molecular Weight | 328.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Progesterone Standards
- (20R)-Progesterone EP Impurity I (CAS 66289-21-2)
- Progesterone Impurity N5 (CAS 35525-27-0)
- Progesterone Impurity N1(Mixture of Diastereomers) (CAS 71658-22-5)
- Progesterone EP Impurity I (S-isomer) (CAS 3986-89-8)
- Progesterone EP Impurity I (CAS 24254-01-1)
- Progesterone Impurity 43 (CAS CATO-C4X-150243)
- Progesterone Impurity 45 (CAS CATO-C4X-150245)
- Progesterone Impurity 51 (CAS 103858-15-7)
Recommended Standards
- Progesterone Impurity 59 (CAS CATO-C4X-150259)
- Progesterone Impurity 60 (CAS CATO-C4X-150260)
- Progesterone Impurity 63 (CAS CATO-C4X-150263)
- Progesterone Impurity 64 (CAS 66875-13-6)
- Cefcapene Impurity 20 (CAS CATO-C4X-182420)
- Norepinephrine impurity 134 (CAS CATO-C4X-1514134)
- Progesterone Impurity 49 (CAS 96790-16-8)
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