5,8-Difluoro-3,3,4,4-tetramethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one CAS 918645-76-8
| CAS No. | 918645-76-8 |
| Molecular Formula | C22H20F2N2O |
| Molecular Weight | 366.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5,8-Difluoro-3,3,4,4-tetramethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one (C22H20F2N2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
5,8-Difluoro-3,3,4,4-tetramethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one (CAS 918645-76-8), molecular formula C22H20F2N2O and molecular weight 366.40 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5,8-Difluoro-3,3,4,4-tetramethyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H20F2N2O |
| Molecular Weight | 366.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoro Standards
- 4,4'-Difluoro-[1,1'-biphenyl]-3,3',5,5'-tetracarboxylic acid (CAS 1628901-94-9)
- 5,6-Difluoro-4-(methoxymethoxy)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-ol (CAS 2883770-87-2)
- 2,5-Difluoro-1,4-Benzenediboronic Acid Bis(pinacol) Ester (CAS 303006-90-8)
- 2,6-difluoro-3,4-diiodopyridine (CAS 685517-78-6)
- 2,6-Difluoro-3,5-Diiodopyridine (CAS 685517-77-5)
- 1,3-Difluoro-2,4-diiodo-benzene (CAS 1208074-68-3)
- 1,2-Difluoro-3,4-diiodobenzene (CAS 933672-12-9)
- 1,2-Difluoro-4,5-diiodobenzene (CAS 210567-10-5)
Recommended Standards
- 4-((4-(Imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl)amino)benzenesulfonamide (CAS 328061-37-6)
- Boc-PEG4-acid (CAS 2244684-38-4)
- (1S,2R)-2-(2-Tosyl-1,2-dihydroxyethyl)-6-fluorochromane (CAS 905454-52-6)
- N-(5-Methylisoxazol-3-yl)-2-((3-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio)acetamide (CAS 852372-81-7)
- Methyl 5-bromo-2-(methylsulfonamido)benzoate (CAS 452350-33-3)
- 4-Methylimidazole (CAS 822-36-6)
- N-(6,8-Dichloro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)acetamide (CAS 64002-02-4)
- 2-(3-Fluoro-4-methoxyphenyl)oxirane (CAS 1016806-32-8)
- 8-Benzyl-3-oxa-1,8-diazaspiro[4.5]Decan-2-one (CAS 945892-89-7)
- 2-(Dimethylamino)pyrimidin-5-ol (CAS 72491-71-5)
- Agrimoniin (CAS 82203-01-8)
- Maprotiline Hydrochloride (CAS 10347-81-6)
- Azacitidine Impurity 33 (CAS CATO-C4X-138833)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com