2-Chloro-8-(trifluoromethyl)quinoline CAS 920494-31-1
| CAS No. | 920494-31-1 |
| Molecular Formula | C10H5ClF3N |
| Molecular Weight | 231.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-8-(trifluoromethyl)quinoline.
2-Chloro-8-(trifluoromethyl)quinoline (CAS 920494-31-1) is a high-purity analytical reference standard with the molecular formula C10H5ClF3N and a molecular weight of 231.60 g/mol.
Based on its molecular formula C10H5ClF3N, 2-Chloro-8-(trifluoromethyl)quinoline contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 231.60 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-8-(trifluoromethyl)quinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H5ClF3N |
| Molecular Weight | 231.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 3-Chloro-7-(trifluoromethyl)quinoline (CAS 104612-21-7)
- 6-Chloro-8-(trifluoromethyl)quinoline (CAS 1065074-68-1)
- 1-chloro-6-(trifluoromethyl)isoquinoline (CAS 1196152-92-7)
- 1-Chloro-7-(trifluoromethyl)isoquinoline (CAS 1196154-02-5)
- 4-Chloro-3-nitrotrifluorotoluene (CAS 121-17-5)
- 8-Chloro-6-(trifluoromethyl)quinoline (CAS 1215206-39-5)
- 1-Chloro-8-trifluoromethyl-isoquinoline (CAS 1283719-92-5)
- 3-Chloro-6-(trifluoromethyl)isoquinoline (CAS 1357945-78-8)
Recommended Standards
- 2-Chloro-7-(trifluoromethyl)quinoline (CAS 83183-56-6)
- 4-Chloro-6-(trifluoromethyl)quinoline (CAS 49713-56-6)
- 2-Chloro-4-(trifluoromethyl)quinoline (CAS 2806-29-3)
- 4-chloro-6,7,8-trifluoro-2-methylquinoline (CAS 951905-11-6)
- Tert-butyl (1S,4R)-5-cyano-2-azabicyclo[2.2.2]Octane-2-carboxylate (CAS 2231670-10-1)
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- 3-(N-dodecylacetamido)propanoic acid (CAS 120167-80-8)
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